Whipple's disease other diagnostic studies
|
Whipple's disease Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Whipple's disease other diagnostic studies On the Web |
|
American Roentgen Ray Society Images of Whipple's disease other diagnostic studies |
|
Risk calculators and risk factors for Whipple's disease other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Bhagyashree Deshmankar M.B.B.S.[2]; Sadaf Sharfaei M.D.[3]
Overview
Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Diagnostic findings of Whipple's disease include, PAS positive inclusions in macrophages of lamina propria. Other diagnostic studies for Whipple's disease include electron microscopy which demonstrate bacteria, immunofluorescent assay to detect antibodies against Tropheryma whipplei and PCR, which demonstrates 16S rRNA gene of Tropheryma whipplei.
Other Diagnostic Studies
- Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of Whipple's disease include:[1]
- PAS positive inclusions in macrophages of lamina propria
- All the organs affected by disease may demonstrate PAS positive macrophages like heart, lungs, CNS, eyes, liver, spleen, joints, and bone marrow.
- Other diagnostic studies for Whipple's disease which confirm the diagnosis include:
- Electron microscopy, which demonstrates:
- Typical trilamellar membrane of Tropheryma whipplei
- Gram positive cell wall structure
- PCR of affected tissue, which demonstrates:
- 16S rRNA gene of Tropheryma whipplei
- Serum immunofluorescent assay, which demonstrates:
- Antibodies against Tropheryma whipplei
- Electron microscopy, which demonstrates:
References
- ↑ Dutly, F.; Altwegg, M. (2001). "Whipple's Disease and "Tropheryma whippelii"". Clinical Microbiology Reviews. 14 (3): 561–583. doi:10.1128/CMR.14.3.561-583.2001. ISSN 0893-8512.