Differential diagnosis
Abbreviations:
RUQ= Right upper quadrant of the abdomen, LFT= Liver function test, SIRS= Systemic inflammatory response syndrome, ERCP= Endoscopic retrograde cholangiopancreatography, N= Normal, AMA= Anti mitochondrial antibodies, LDH= Lactate dehydrogenase, GI= Gastrointestinal, CT= Computed tomography
| Classification of jaundice based on etiology
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Disease
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History and clinical manifestations
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Diagnosis
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| Lab Findings
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Other blood tests
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Other diagnostic
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| Family history
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Fever
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RUQ Pain
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Pruritis
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AST
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ALT
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ALK
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BLR Indirect
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BLR Direct
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Viral serology
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| Jaundice
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Hepatocellular Jaundice
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Hemochromatosis
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+
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-
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-/+
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-
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↑
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↑
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↑/N
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↑/N
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N
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-
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Ferritin ↑
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Liver biopsy
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| Wilson's disease
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+
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-
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-/+
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-
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↑
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↑
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N
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↑/N
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N
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-
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Serum cerulloplasmin ↑
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Liver biopsy
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| Viral hepatitis
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-
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-/+
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-
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-
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↑
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↑
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N
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↑/N
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N
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+
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Specific viral antibody for each type
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| Alcoholic hepatitis
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-
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-
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-
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-
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↑
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↑↑
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N
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↑/N
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N
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-
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-
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-
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| Drug induced hepatitis
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-
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-/+
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-
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-
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↑
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↑
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N
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↑/N
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N
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-
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-
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-
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| Autoimmune hepatitis
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-/+
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-
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-
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-/+
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↑
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↑
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N
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↑/N
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N
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-
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Anti-LKM antibody
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Liver biopsy
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| Cholestatic Jaundice
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Common bile duct stone
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CT/ERCP
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| Hepatitis A cholestatic type
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Abdominal ultrasound
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| EBV / CMV
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| Primary biliary cirrhosis
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| Primary sclerosing cholangitis
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| Isolated Jaundice
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Crigler-Najjar
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| Gilbert
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| Rotor syndrome
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| Dubin-Johnson syndrome
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| Hereditory spherocytosis
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| G6PD deficiency
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| Thalassemia
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| Sickle cell disease
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| Paroxismal nocturnal hemoglobinoria
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| Immune hemolysis
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