Sandbox: manpreet kaur

Salvage therapies for Helicobacter pylori infection
Regimen	Drugs(doses)	Dosing frequency	Duration(days)	FDA approval
Bismuth quadruple	PPI(standard dose) Bismuth subciitrate(120-300mg or sub salicylate(300mg) Tetracycline(500mg) Metronidazole(500mg)	BID QID QID TID or QID	14	NO(a)
Levofloxacin triple	PPI(standard dose) Levofloxacin (500mg) Amoxicillin(1gm)	BID QD BID	14	NO
Concomitant	PPI(standard dose) Clarithromycin(500mg) Amoxicillin(1gm) Nitroimidazole(500mg)	BID BID BID BID or TID	10-14	NO
Rifabutin triple	PPI(standard dose) Rifabutin(300mg) Amoxicillin(1gm)	BID QD BID	10	NO
High-dose dual	PPI(standard to double dose) Amoxicillin(1gm TID or 750mg QID)	TID or QID TID or QID	14	NO

(a)PPI,Bismuth,tetracyclin and metronidazole prescribed separately is not an FDA-approved treatment regimen.However,Pylera,a combination product containing bimuth subcitrate,tetracyclin and metronidazole combined with a PPI for 10 days is an FDA-approved treatment regimen

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

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