Hepatocellular adenoma risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
The most potent risk factor in the development of hepatocellular adenoma is use of oral contraceptive pills.[1]
Hepatocellular adenoma risk factors
- The most potent risk factor in the development of hepatocellular adenoma is use of oral contraceptive pills.[1]
- Drospirenone and Ethinyl estradiol
- Norethindrone acetate and Ethinyl estradiol
- Norgestimate and Ethinyl estradiol
- Norgestrel and Ethinyl estradiol
- The risk is proportional to:[2]
- Hormonal dose
- Duration of medication
- Other risk factors include:[2]
- Clomiphene
- Methyl testosterone
- Danazol
- Klinefelter's syndrome
- Types I, III and IV glycogen storage disease
- Familial adenomatous polyposis
Risk factors for malignant transformation
The risk factor for malignant transformation of hepatic adenoma to hepatocellular carcinoma is:[3]
- Gender (men)
- Size (> 8 cm)
- Subtype (beta-catenin-activated HCA)
References
- ↑ 1.0 1.1 How do oral contraceptives affect liver cancer risk. National Cancer Institute 2015. http://www.cancer.gov/about-cancer/causes-prevention/risk/hormones/oral-contraceptives-fact-sheet
- ↑ 2.0 2.1 Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
- ↑ Aamann L, Schultz N, Fallentin E, Hamilton-Dutoit S, Vogel I, Grønbæk H (2015). "[Hepatocellular adenoma - new classification and recommendations]". Ugeskr Laeger. 177 (12). PMID 25786843.