Primary sclerosing cholangitis classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]
Overview
Primary sclerosing cholangitis may be classified according to the size of bile ducts involved, as well as its association with autoimmune hepatitis. The 3 main subtypes are the classic subtype, small ducts subtype and primary sclerosing cholangitis associated with autoimmune hepatitis.
Classification
Primary sclerosing cholangitis may be divided into 3 subtypes, according to the type of ducts involved, as well as its association with autoimmune hepatitis:[1][2][3][4]
| Subtype | Ducts Involved | Diagnostic Procedure | Histopathology |
|---|---|---|---|
| Classic | Small and large bile ducts | MRCP, ERCP | Mixed inflammatory cells around bile ducts; nonspecific and nondiagnostic finding |
| Small duct | Small bile ducts only | Liver biopsy | Mixed inflammatory cells around bile ducts; nonspecific and nondiagnostic finding |
| Associated with autoimmune hepatitis | Small and large bile ducts | MRCP, ERCP | Lymphoplasmacytic infiltrate, associated with interface hepatitis |
References
- ↑ Lazaridis KN, LaRusso NF (2016). "Primary Sclerosing Cholangitis". N. Engl. J. Med. 375 (12): 1161–70. doi:10.1056/NEJMra1506330. PMID 27653566.
- ↑ Angulo P, Maor-Kendler Y, Lindor KD (2002). "Small-duct primary sclerosing cholangitis: a long-term follow-up study". Hepatology. 35 (6): 1494–500. doi:10.1053/jhep.2002.33202. PMID 12029635.
- ↑ Feldstein AE, Perrault J, El-Youssif M, Lindor KD, Freese DK, Angulo P (2003). "Primary sclerosing cholangitis in children: a long-term follow-up study". Hepatology. 38 (1): 210–7. doi:10.1053/jhep.2003.50289. PMID 12830004.
- ↑ Kaya M, Angulo P, Lindor KD (2000). "Overlap of autoimmune hepatitis and primary sclerosing cholangitis: an evaluation of a modified scoring system". J. Hepatol. 33 (4): 537–42. PMID 11059857.