Cholangitis primary prevention

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farwa Haideri [2]

Overview

Although reestablishing biliary drainage is the main focus of treatment, antibiotics play an important role in the management of cholangitis.

There are no established measures for the primary prevention of cholangitis in otherwise healthy people.
Treatment of gallstones, tumors, and infestations of parasites may reduce the risk for some people.
Patients undergoing ERCP should have prophylactic antibiotics.

Patients with compromised biliary systems prone to developing recurrent cholangitis may benefit from antibiotic maintenance therapy, given daily in lower-than-therapeutic dosages.^[1]
- A metal or plastic stent within the bile system after the procedures involving drainage of the biliary tree, may be needed to prevent recurrence.^[2]

↑ van den Hazel SJ, Speelman P, Tytgat GN, Dankert J, van Leeuwen DJ (1994). "Role of antibiotics in the treatment and prevention of acute and recurrent cholangitis". Clin. Infect. Dis. 19 (2): 279–86. PMID 7986900.
↑ Butler SJ, Landon M (1979). "Transglutaminase-catalysed labelling of cytochrome c and cytochrome c oxidase [proceedings]". Biochem. Soc. Trans. 7 (2): 397–8. PMID 34544.