Lactose intolerance historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]
Overview
Historical Perspective
Discovery
- Lactose intolerance first discovered by Hippocrate, ancient Greek physician 2500 years ago.[1]
- In 1906, Pimmer was the first scientist that discovered lactase enzyme in the intestine of infant dogs, pigs, and rats; also he found that this enzyme decreases in the adult intestine of these animals.[1]
- In 1959, Durand and Holzei et al decribed congenital lactase deficiency[1]
- The association between ethnic and lactose intolerance was discovered in 1966 by Bayless and Rosensweig and in 1968 by Neale.
- In early 1970s,lactase-phlorizin hydrolase (LPH) gene mutations were first implicated in the pathogenesis of lactose intolerance.[2]
Landmark Events in the Development of Treatment Strategies
- In1978, breath hydrogen test was used by Levitt, to diagnose lactose intolerance.[3]
References
- ↑ 1.0 1.1 1.2 Neale G (1973). "The geographical incidence of lactase deficiency". Pathol Microbiol (Basel). 39 (3): 238–47. PMID 4718561.
- ↑ Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Järvelä I (2002). "Identification of a variant associated with adult-type hypolactasia". Nat. Genet. 30 (2): 233–7. doi:10.1038/ng826. PMID 11788828.
- ↑ Rana SV, Malik A (2014). "Hydrogen breath tests in gastrointestinal diseases". Indian J Clin Biochem. 29 (4): 398–405. doi:10.1007/s12291-014-0426-4. PMC 4175689. PMID 25298621.