SPEN

Spen homolog, transcriptional regulator (Drosophila)
File:PBB Protein SPEN image.jpg PDB rendering based on 1ow1.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ow1​
Identifiers
Symbols	SPEN ; KIAA0929; MINT; RP1-134O19.1; SHARP
External IDs	Template:MGI HomoloGene: 8992
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SPEN 201997 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Spen homolog, transcriptional regulator (Drosophila), also known as SPEN, is a human gene.

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.

Further reading

• Ternovskaia LN, Prokhorova LG, Moroz VM (1977). "[Antagonistic interrelationships between the staphylococci and Sarcina isolated from the upper respiratory tracts of virtually healthy persons]". Antibiotiki. 21 (12): 1072–5. PMID 1020939.CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. PMID 10231032.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Newberry EP, Latifi T, Towler DA (1999). "The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter". Biochemistry. 38 (33): 10678–90. doi:10.1021/bi990967j. PMID 10451362.CS1 maint: Multiple names: authors list (link)
• Shi Y, Downes M, Xie W; et al. (2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes Dev. 15 (9): 1140–51. doi:10.1101/gad.871201. PMID 11331609.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shi Y, Hon M, Evans RM (2002). "The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2613–8. doi:10.1073/pnas.052707099. PMID 11867749.CS1 maint: Multiple names: authors list (link)
• Oswald F, Kostezka U, Astrahantseff K; et al. (2002). "SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway". EMBO J. 21 (20): 5417–26. PMID 12374742.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ariyoshi M, Schwabe JW (2003). "A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling". Genes Dev. 17 (15): 1909–20. doi:10.1101/gad.266203. PMID 12897056.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dotzlaw H, Papaioannou M, Moehren U; et al. (2004). "Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor". Mol. Cell. Endocrinol. 213 (1): 79–85. doi:10.1016/j.mce.2003.10.036. PMID 15062576.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vadlamudi RK, Manavathi B, Singh RR; et al. (2005). "An essential role of Pak1 phosphorylation of SHARP in Notch signaling". Oncogene. 24 (28): 4591–6. doi:10.1038/sj.onc.1208672. PMID 15824732.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li J, Wang J, Yang X; et al. (2007). "The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8". Mol. Cell. Biochem. 288 (1–2): 151–7. doi:10.1007/s11010-006-9131-9. PMID 16583136.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Feng Y, Bommer GT, Zhai Y; et al. (2007). "Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation". Cancer Res. 67 (2): 482–91. doi:10.1158/0008-5472.CAN-06-2314. PMID 17234755.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)