ABL2

V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
PDB rendering based on 1ab2.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ab2​, 1abo​, 1abq​, 1bbz​, 1fpu​, 1iep​, 1ju5​, 1m52​, 1opj​, 2e2b​, 2f4j​, 2g1t​, 2g2f​, 2g2h​, 2g2i​, 2gqg​, 2hiw​, 2hyy​, 2hz0​, 2hz4​, 2hzi​, 2hzn​
Identifiers
Symbols	ABL2 ; ABLL; ARG
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5278
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene), also known as ABL2, is a human gene.

ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.

Further reading

• Pendergast AM (2003). "The Abl family kinases: mechanisms of regulation and signaling". Adv. Cancer Res. 85: 51–100. PMID 12374288.
• Muller AJ, Pendergast AM, Havlik MH; et al. (1992). "A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction". Mol. Cell. Biol. 12 (11): 5087–93. PMID 1383690.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kruh GD, Perego R, Miki T, Aaronson SA (1990). "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases". Proc. Natl. Acad. Sci. U.S.A. 87 (15): 5802–6. PMID 2198571.CS1 maint: Multiple names: authors list (link)
• Kruh GD, King CR, Kraus MH; et al. (1987). "A novel human gene closely related to the abl proto-oncogene". Science. 234 (4783): 1545–8. PMID 3787260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Wang B, Kruh GD (1996). "Subcellular localization of the Arg protein tyrosine kinase". Oncogene. 13 (1): 193–7. PMID 8700546.
• Wang B, Mysliwiec T, Feller SM; et al. (1996). "Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk". Oncogene. 13 (7): 1379–85. PMID 8875975.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang B, Golemis EA, Kruh GD (1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". J. Biol. Chem. 272 (28): 17542–50. PMID 9211900.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koval AP, Blakesley VA, Roberts CT; et al. (1998). "Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor". Biochem. J. 330 ( Pt 2): 923–32. PMID 9480911.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hashimoto Y, Katayama H, Kiyokawa E; et al. (1998). "Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor". J. Biol. Chem. 273 (27): 17186–91. PMID 9642287.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Danial NN, Losman JA, Lu T; et al. (1998). "Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation". Mol. Cell. Biol. 18 (11): 6795–804. PMID 9774693.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cao C, Ren X, Kharbanda S; et al. (2001). "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress". J. Biol. Chem. 276 (15): 11465–8. doi:10.1074/jbc.C100050200. PMID 11278261.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu HH, Zisch AH, Dodelet VC, Pasquale EB (2001). "Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor". Oncogene. 20 (30): 3995–4006. doi:10.1038/sj.onc.1204524. PMID 11494128.CS1 maint: Multiple names: authors list (link)
• Endo A, Nagashima K, Kurose H; et al. (2002). "Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII". J. Biol. Chem. 277 (26): 23747–54. doi:10.1074/jbc.M111794200. PMID 11956190.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abassi YA, Vuori K (2002). "Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling". EMBO J. 21 (17): 4571–82. PMID 12198159.
• Bianchi C, Muradore I, Corizzato M; et al. (2002). "The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation". FEBS Lett. 527 (1–3): 216–222. PMID 12220663.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Salomon AR, Ficarro SB, Brill LM; et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. doi:10.1073/pnas.2436191100. PMID 12522270.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)