GBP1

Guanylate binding protein 1, interferon-inducible, 67kDa
PDB rendering based on 1dg3.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1dg3​, 1f5n​, 2b8w​, 2b92​, 2bc9​, 2d4h​
Identifiers
Symbols	GBP1 ;
External IDs	Template:OMIM5 HomoloGene: 55626
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Guanylate binding protein 1, interferon-inducible, 67kDa, also known as GBP1, is a human gene.

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3

Further reading

• Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects". Mol. Cell Proteomics. 1 (11): 845–67. PMID 12488461.
• Naschberger E, Bauer M, Stürzl M (2006). "Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases". Adv. Enzyme Regul. 45: 215–27. doi:10.1016/j.advenzreg.2005.02.011. PMID 16005050.CS1 maint: Multiple names: authors list (link)
• Cheng YS, Patterson CE, Staeheli P (1991). "Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP". Mol. Cell. Biol. 11 (9): 4717–25. PMID 1715024.CS1 maint: Multiple names: authors list (link)
• Strehlow I, Lohmann-Matthes ML, Decker T (1994). "The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1". Gene. 144 (2): 295–9. PMID 7518790.CS1 maint: Multiple names: authors list (link)
• Nantais DE, Schwemmle M, Stickney JT; et al. (1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1". J. Leukoc. Biol. 60 (3): 423–31. PMID 8830800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saunders NA, Smith RJ, Jetten AM (1999). "Regulation of guanylate-binding protein expression in interferon-gamma-treated human epidermal keratinocytes and squamous cell carcinoma cells". J. Invest. Dermatol. 112 (6): 977–83. doi:10.1046/j.1523-1747.1999.00611.x. PMID 10383748.CS1 maint: Multiple names: authors list (link)
• Prakash B, Praefcke GJ, Renault L; et al. (2000). "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins". Nature. 403 (6769): 567–71. doi:10.1038/35000617. PMID 10676968.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kumar S, Li Q, Dua A; et al. (2001). "Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation". J. Clin. Endocrinol. Metab. 86 (6): 2420–7. PMID 11397834.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guenzi E, Töpolt K, Cornali E; et al. (2001). "The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines". EMBO J. 20 (20): 5568–77. doi:10.1093/emboj/20.20.5568. PMID 11598000.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lubeseder-Martellato C, Guenzi E, Jörg A; et al. (2002). "Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases". Am. J. Pathol. 161 (5): 1749–59. PMID 12414522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adkins JN, Varnum SM, Auberry KJ; et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell Proteomics. 1 (12): 947–55. PMID 12543931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guenzi E, Töpolt K, Lubeseder-Martellato C; et al. (2003). "The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression". EMBO J. 22 (15): 3772–82. doi:10.1093/emboj/cdg382. PMID 12881412.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Naschberger E, Werner T, Vicente AB; et al. (2004). "Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells". Biochem. J. 379 (Pt 2): 409–20. doi:10.1042/BJ20031873. PMID 14741045.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Praefcke GJ, Kloep S, Benscheid U; et al. (2004). "Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis". J. Mol. Biol. 344 (1): 257–69. doi:10.1016/j.jmb.2004.09.026. PMID 15504415.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Modiano N, Lu YE, Cresswell P (2005). "Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8680–5. doi:10.1073/pnas.0503227102. PMID 15937107.CS1 maint: Multiple names: authors list (link)
• Ghosh A, Praefcke GJ, Renault L; et al. (2006). "How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP". Nature. 440 (7080): 101–4. doi:10.1038/nature04510. PMID 16511497.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)