PDPN

Podoplanin
Identifiers
Symbols	PDPN ; GP40; GP36; Gp38; HT1A-1; OTS8; PA2.26; T1A; T1A-2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4729
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PDPN 221898 at tn.png
File:PBB GE PDPN 204879 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Podoplanin, also known as PDPN, is a human gene.

This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Wicki A, Christofori G (2007). "The potential role of podoplanin in tumour invasion". Br. J. Cancer. 96 (1): 1–5. doi:10.1038/sj.bjc.6603518. PMID 17179989.
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA; et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Ma T, Yang B, Matthay MA, Verkman AS (1998). "Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels". Am. J. Respir. Cell Mol. Biol. 19 (1): 143–9. PMID 9651190.CS1 maint: Multiple names: authors list (link)
• Zimmer G, Oeffner F, Von Messling V; et al. (1999). "Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium". Biochem. J. 341 ( Pt 2): 277–84. PMID 10393083.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato Y, Fujita N, Kunita A; et al. (2004). "Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors". J. Biol. Chem. 278 (51): 51599–605. doi:10.1074/jbc.M309935200. PMID 14522983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaneko M, Kato Y, Kunita A; et al. (2004). "Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells". J. Biol. Chem. 279 (37): 38838–43. doi:10.1074/jbc.M407210200. PMID 15231832.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martín-Villar E, Scholl FG, Gamallo C; et al. (2005). "Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas". Int. J. Cancer. 113 (6): 899–910. doi:10.1002/ijc.20656. PMID 15515019.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schacht V, Dadras SS, Johnson LA; et al. (2005). "Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors". Am. J. Pathol. 166 (3): 913–21. PMID 15743802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hultgård-Ekwall AK, Mayerl C, Rubin K; et al. (2006). "An interstitial network of podoplanin-expressing cells in the human endolymphatic duct". J. Assoc. Res. Otolaryngol. 7 (1): 38–47. doi:10.1007/s10162-005-0021-8. PMID 16408168.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dumoff KL, Chu CS, Harris EE; et al. (2006). "Low podoplanin expression in pretreatment biopsy material predicts poor prognosis in advanced-stage squamous cell carcinoma of the uterine cervix treated by primary radiation". Mod. Pathol. 19 (5): 708–16. doi:10.1038/modpathol.3800580. PMID 16528371.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Omachi T, Kawai Y, Mizuno R; et al. (2007). "Immunohistochemical demonstration of proliferating lymphatic vessels in colorectal carcinoma and its clinicopathological significance". Cancer Lett. 246 (1–2): 167–72. doi:10.1016/j.canlet.2006.02.013. PMID 16574316.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mishima K, Kato Y, Kaneko MK; et al. (2007). "Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression". Acta Neuropathol. 111 (5): 483–8. doi:10.1007/s00401-006-0063-y. PMID 16596424.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wicki A, Lehembre F, Wick N; et al. (2006). "Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton". Cancer Cell. 9 (4): 261–72. doi:10.1016/j.ccr.2006.03.010. PMID 16616332.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mishima K, Kato Y, Kaneko MK; et al. (2007). "Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma". Acta Neuropathol. 111 (6): 563–8. doi:10.1007/s00401-006-0033-4. PMID 16718353.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)