DAP3

Death associated protein 3
Identifiers
Symbols	DAP3 ; DAP-3; DKFZp686G12159; MGC126058; MGC126059; MRP-S29; MRPS29; bMRP-10
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3404
Gene ontology Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Death associated protein 3, also known as DAP3, is a human gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Splice variants that differ in the 5' UTR have been found for this gene; both variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q.

Further reading

• Kissil JL, Deiss LP, Bayewitch M; et al. (1996). "Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death". J. Biol. Chem. 270 (46): 27932–6. PMID 7499268.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Kissil JL, Kimchi A (1997). "Assignment of death associated protein 3 (DAP3) to human chromosome 1q21 by in situ hybridization". Cytogenet. Cell Genet. 77 (3–4): 252. PMID 9284927.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hulkko SM, Wakui H, Zilliacus J (2001). "The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function". Biochem. J. 349 Pt 3: 885–93. PMID 10903152.CS1 maint: Multiple names: authors list (link)
• Morgan CJ, Jacques C, Savagner F; et al. (2001). "A conserved N-terminal sequence targets human DAP3 to mitochondria". Biochem. Biophys. Res. Commun. 280 (1): 177–81. doi:10.1006/bbrc.2000.4119. PMID 11162496.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cavdar Koc E, Ranasinghe A, Burkhart W; et al. (2001). "A new face on apoptosis: death-associated protein 3 and PDCD9 are mitochondrial ribosomal proteins". FEBS Lett. 492 (1–2): 166–70. PMID 11248257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cavdar Koc E, Burkhart W, Blackburn K; et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyazaki T, Reed JC (2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol. 2 (6): 493–500. doi:10.1038/88684. PMID 11376335.
• Suzuki T, Terasaki M, Takemoto-Hori C; et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kenmochi N, Suzuki T, Uechi T; et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berger T, Kretzler M (2002). "Interaction of DAP3 and FADD only after cellular disruption". Nat. Immunol. 3 (1): 3–5. doi:10.1038/ni0102-3b. PMID 11753396.
• Hulkko SM, Zilliacus J (2002). "Functional interaction between the pro-apoptotic DAP3 and the glucocorticoid receptor". Biochem. Biophys. Res. Commun. 295 (3): 749–55. PMID 12099703.
• Berger T, Kretzler M (2002). "TRAIL-induced apoptosis is independent of the mitochondrial apoptosis mediator DAP3". Biochem. Biophys. Res. Commun. 297 (4): 880–4. PMID 12359235.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. PMID 12706105.
• Mukamel Z, Kimchi A (2004). "Death-associated protein 3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death". J. Biol. Chem. 279 (35): 36732–8. doi:10.1074/jbc.M400041200. PMID 15175341.
• Hirota T, Obara K, Matsuda A; et al. (2004). "Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma". J. Hum. Genet. 49 (7): 370–5. doi:10.1007/s10038-004-0161-4. PMID 15179560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyazaki T, Shen M, Fujikura D; et al. (2004). "Functional role of death-associated protein 3 (DAP3) in anoikis". J. Biol. Chem. 279 (43): 44667–72. doi:10.1074/jbc.M408101200. PMID 15302871.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sasaki H, Ide N, Yukiue H; et al. (2005). "Arg and DAP3 expression was correlated with human thymoma stage". Clin. Exp. Metastasis. 21 (6): 507–13. PMID 15679048.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)