PIK3C2B

Phosphoinositide-3-kinase, class 2, beta polypeptide
Identifiers
Symbols	PIK3C2B ; C2-PI3K; DKFZp686G16234
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20582
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PIK3C2B 204484 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phosphoinositide-3-kinase, class 2, beta polypeptide, also known as PIK3C2B, is a human gene.

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.

Further reading

• Lee C, Liu QH, Tomkowicz B; et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kozutsumi H, Toyoshima H, Hagiwara K; et al. (1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene. 9 (10): 2991–8. PMID 8084603.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Milani D, Mazzoni M, Borgatti P; et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". J. Biol. Chem. 271 (38): 22961–4. PMID 8798481.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brown RA, Ho LK, Weber-Hall SJ; et al. (1997). "Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K". Biochem. Biophys. Res. Commun. 233 (2): 537–44. doi:10.1006/bbrc.1997.6495. PMID 9144573.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueno H, Honda H, Nakamoto T; et al. (1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. PMID 9223670.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol. 27 (9): 2457–65. PMID 9341793.CS1 maint: Multiple names: authors list (link)
• Borgatti P, Zauli G, Colamussi ML; et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805–11. PMID 9394803.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun. 242 (2): 332–7. PMID 9446795.CS1 maint: Multiple names: authors list (link)
• Milani D, Mazzoni M, Zauli G; et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. PMID 9708406.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jauliac S, Mazerolles F, Jabado N; et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". Eur. J. Immunol. 28 (10): 3183–91. PMID 9808187.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arcaro A, Volinia S, Zvelebil MJ; et al. (1999). "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity". J. Biol. Chem. 273 (49): 33082–90. PMID 9830063.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arcaro A, Zvelebil MJ, Wallasch C; et al. (2000). "Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors". Mol. Cell. Biol. 20 (11): 3817–30. PMID 10805725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes". Blood. 97 (2): 352–8. PMID 11154208.CS1 maint: Multiple names: authors list (link)
• Zauli G, Milani D, Mirandola P; et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wheeler M, Domin J (2001). "Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2". Mol. Cell. Biol. 21 (19): 6660–7. PMID 11533253.
• Deregibus MC, Cantaluppi V, Doublier S; et al. (2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells". J. Biol. Chem. 277 (28): 25195–202. doi:10.1074/jbc.M200921200. PMID 11994280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism". J. Immunol. 169 (1): 254–60. PMID 12077252.CS1 maint: Multiple names: authors list (link)
• Arcaro A, Khanzada UK, Vanhaesebroeck B; et al. (2002). "Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation". EMBO J. 21 (19): 5097–108. PMID 12356726.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Visnjić D, Crljen V, Curić J; et al. (2002). "The activation of nuclear phosphoinositide 3-kinase C2beta in all-trans-retinoic acid-differentiated HL-60 cells". FEBS Lett. 529 (2–3): 268–74. PMID 12372612.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)