Involucrin

Involucrin
Identifiers
Symbols	IVL ;
External IDs	Template:OMIM5 HomoloGene: 86915
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Involucrin, also known as IVL, is a human gene.

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.

Further reading

• Eckert RL, Crish JF, Efimova T; et al. (2004). "Regulation of involucrin gene expression". J. Invest. Dermatol. 123 (1): 13–22. doi:10.1111/j.0022-202X.2004.22723.x. PMID 15191537.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rice RH, Green H (1980). "Presence in human epidermal cells of a soluble protein precursor of the cross-linked envelope: activation of the cross-linking by calcium ions". Cell. 18 (3): 681–94. PMID 42494.
• Yaffe MB, Beegen H, Eckert RL (1992). "Biophysical characterization of involucrin reveals a molecule ideally suited to function as an intermolecular cross-bridge of the keratinocyte cornified envelope". J. Biol. Chem. 267 (17): 12233–8. PMID 1601889.CS1 maint: Multiple names: authors list (link)
• Simon M, Green H (1989). "The glutamine residues reactive in transglutaminase-catalyzed cross-linking of involucrin". J. Biol. Chem. 263 (34): 18093–8. PMID 2461365.
• Eckert RL, Green H (1986). "Structure and evolution of the human involucrin gene". Cell. 46 (4): 583–9. PMID 2873896.
• Heller M, Flemington E, Kieff E, Deininger P (1985). "Repeat arrays in cellular DNA related to the Epstein-Barr virus IR3 repeat". Mol. Cell. Biol. 5 (3): 457–65. PMID 2985954.CS1 maint: Multiple names: authors list (link)
• Welter JF, Crish JF, Agarwal C, Eckert RL (1995). "Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity". J. Biol. Chem. 270 (21): 12614–22. PMID 7759510.CS1 maint: Multiple names: authors list (link)
• Volz A, Korge BP, Compton JG; et al. (1994). "Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21". Genomics. 18 (1): 92–9. doi:10.1006/geno.1993.1430. PMID 8276421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi H, Iizuka H (1993). "Analysis of the 5'-upstream promoter region of human involucrin gene: activation by 12-O-tetradecanoylphorbol-13-acetate". J. Invest. Dermatol. 100 (1): 10–5. PMID 8380829.
• Lopez-Bayghen E, Vega A, Cadena A; et al. (1996). "Transcriptional analysis of the 5'-noncoding region of the human involucrin gene". J. Biol. Chem. 271 (1): 512–20. PMID 8550612.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi H, Kobayashi H, Matsuo S, Iizuka H (1996). "Repression of involucrin gene expression by transcriptional enhancer factor 1 (TEF-1)". Arch. Dermatol. Res. 287 (8): 740–6. PMID 8554386.CS1 maint: Multiple names: authors list (link)
• Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J. Biol. Chem. 272 (3): 2021–30. PMID 8999895.
• Robinson NA, Lapic S, Welter JF, Eckert RL (1997). "S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes". J. Biol. Chem. 272 (18): 12035–46. PMID 9115270.CS1 maint: Multiple names: authors list (link)
• Ng DC, Su MJ, Kim R, Bikle DD (2004). "Regulation of involucrin gene expression by calcium in normal human keratinocytes". Front. Biosci. 1: a16–24. PMID 9159190.CS1 maint: Multiple names: authors list (link)
• Banks EB, Crish JF, Welter JF, Eckert RL (1998). "Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites". Biochem. J. 331 ( Pt 1): 61–8. PMID 9512462.CS1 maint: Multiple names: authors list (link)
• Marekov LN, Steinert PM (1998). "Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope". J. Biol. Chem. 273 (28): 17763–70. PMID 9651377.
• Crish JF, Zaim TM, Eckert RL (1998). "The distal regulatory region of the human involucrin promoter is required for expression in epidermis". J. Biol. Chem. 273 (46): 30460–5. PMID 9804813.CS1 maint: Multiple names: authors list (link)
• Lee CH, Marekov LN, Kim S; et al. (2000). "Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes". FEBS Lett. 477 (3): 268–72. PMID 10908733.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Candi E, Oddi S, Terrinoni A; et al. (2001). "Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro". J. Biol. Chem. 276 (37): 35014–23. doi:10.1074/jbc.M010157200. PMID 11443109.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Crish JF, Bone F, Banks EB, Eckert RL (2002). "The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation". Oncogene. 21 (5): 738–47. doi:10.1038/sj.onc.1205038. PMID 11850802.CS1 maint: Multiple names: authors list (link)