KIF2C

Kinesin family member 2C
File:PBB Protein KIF2C image.jpg PDB rendering based on 1v8j.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1v8j​, 1v8k​, 2heh​
Identifiers
Symbols	KIF2C ; KNSL6; MCAK
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21355
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE KIF2C 211519 s at tn.png
File:PBB GE KIF2C 209408 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kinesin family member 2C, also known as KIF2C, is a human gene.

The protein encoded by this gene is a member of kinesin-like protein family. Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.

Further reading

• Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMID 11416179.CS1 maint: Multiple names: authors list (link)
• Kim IG, Jun DY, Sohn U, Kim YH (1998). "Cloning and expression of human mitotic centromere-associated kinesin gene". Biochim. Biophys. Acta. 1359 (3): 181–6. PMID 9434124.CS1 maint: Multiple names: authors list (link)
• Maney T, Hunter AW, Wagenbach M, Wordeman L (1998). "Mitotic centromere-associated kinesin is important for anaphase chromosome segregation". J. Cell Biol. 142 (3): 787–801. PMID 9700166.CS1 maint: Multiple names: authors list (link)
• Wordeman L, Wagenbach M, Maney T (2000). "Mutations in the ATP-binding domain affect the subcellular distribution of mitotic centromere-associated kinesin (MCAK)". Cell Biol. Int. 23 (4): 275–86. doi:10.1006/cbir.1999.0359. PMID 10600236.CS1 maint: Multiple names: authors list (link)
• Sugata N, Li S, Earnshaw WC; et al. (2001). "Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes". Hum. Mol. Genet. 9 (19): 2919–26. PMID 11092768.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maney T, Wagenbach M, Wordeman L (2001). "Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin". J. Biol. Chem. 276 (37): 34753–8. doi:10.1074/jbc.M106626200. PMID 11466324.CS1 maint: Multiple names: authors list (link)
• Cheng LJ, Zhou ZM, Li JM; et al. (2002). "Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis". Life Sci. 71 (23): 2741–57. PMID 12383881.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cassimeris L, Morabito J (2004). "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Mol. Biol. Cell. 15 (4): 1580–90. doi:10.1091/mbc.E03-07-0544. PMID 14718566.
• Ganem NJ, Compton DA (2004). "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK". J. Cell Biol. 166 (4): 473–8. doi:10.1083/jcb.200404012. PMID 15302853.
• Newton CN, Wagenbach M, Ovechkina Y; et al. (2004). "MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitro". FEBS Lett. 572 (1–3): 80–4. doi:10.1016/j.febslet.2004.06.093. PMID 15304328.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moore AT, Rankin KE, von Dassow G; et al. (2005). "MCAK associates with the tips of polymerizing microtubules". J. Cell Biol. 169 (3): 391–7. doi:10.1083/jcb.200411089. PMID 15883193.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ganem NJ, Upton K, Compton DA (2006). "Efficient mitosis in human cells lacking poleward microtubule flux". Curr. Biol. 15 (20): 1827–32. doi:10.1016/j.cub.2005.08.065. PMID 16243029.CS1 maint: Multiple names: authors list (link)
• Helenius J, Brouhard G, Kalaidzidis Y; et al. (2006). "The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends". Nature. 441 (7089): 115–9. doi:10.1038/nature04736. PMID 16672973.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun Y, Huang YC, Xu QZ; et al. (2006). "HIV-1 Tat depresses DNA-PK(CS) expression and DNA repair, and sensitizes cells to ionizing radiation". Int. J. Radiat. Oncol. Biol. Phys. 65 (3): 842–50. doi:10.1016/j.ijrobp.2006.02.040. PMID 16751065.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)