UCK2

Uridine-cytidine kinase 2
File:PBB Protein UCK2 image.jpg PDB rendering based on 1udw.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1udw​, 1uei​, 1uej​, 1ufq​, 1uj2​, 1xrj​
Identifiers
Symbols	UCK2 ; TSA903; UK; UMPK
External IDs	Template:OMIM5 Template:MGI HomoloGene: 40850
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE UCK2 209825 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Uridine-cytidine kinase 2, also known as UCK2, is a human gene.

The protein encoded by this gene catalyzes the phosphorylation of uridine monophosphate to uridine diphosphate. This is the first step in the production of the pyrimidine nucleoside triphosphates required for RNA and DNA synthesis. In addition, an allele of this gene may play a role in mediating nonhumoral immunity to Hemophilus influenzae type B.

Further reading

• Satlin A, Kucherlapati R, Ruddle FH (1976). "Assignment of the gene for human uridine monophosphate kinase to chromosome 1 using somatic cell hybrid clone panels". Cytogenet. Cell Genet. 15 (3): 146–52. PMID 172293.CS1 maint: Multiple names: authors list (link)
• Jamil TP, Swallow DM, Povey S (1979). "A comparative study of the age-related patterns of decay of some nucleoside monophosphate kinases in human red cells". Biochem. Genet. 16 (11–12): 1219–32. PMID 220950.CS1 maint: Multiple names: authors list (link)
• Ozaki K, Kuroki T, Hayashi S, Nakamura Y (1997). "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method". Genomics. 36 (2): 316–9. doi:10.1006/geno.1996.0467. PMID 8812458.CS1 maint: Multiple names: authors list (link)
• Van Rompay AR, Johansson M, Karlsson A (1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme". Mol. Pharmacol. 56 (3): 562–9. PMID 10462544.CS1 maint: Multiple names: authors list (link)
• Van Rompay AR, Norda A, Lindén K; et al. (2001). "Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases". Mol. Pharmacol. 59 (5): 1181–6. PMID 11306702.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Komatsu N, Kimura Y, Kido A, Oya M (2001). "Polymorphism of uridine monophosphate kinase: population study in Japanese and phenotyping in bloodstains". Int. J. Legal Med. 104 (1): 13–6. PMID 11453085.CS1 maint: Multiple names: authors list (link)
• Koizumi K, Shimamoto Y, Azuma A; et al. (2001). "Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells". Int. J. Mol. Med. 8 (3): 273–8. PMID 11494055.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pearman AT, Castro-Faria-Neto HC, McIntyre TM; et al. (2001). "Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region". Life Sci. 69 (20): 2361–70. PMID 11681623.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liou JY, Dutschman GE, Lam W; et al. (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Res. 62 (6): 1624–31. PMID 11912132.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kashuba E, Kashuba V, Sandalova T; et al. (2002). "Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase". BMC Cell Biol. 3: 23. PMID 12199906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pasti C, Gallois-Montbrun S, Munier-Lehmann H; et al. (2003). "Reaction of human UMP-CMP kinase with natural and analog substrates". Eur. J. Biochem. 270 (8): 1784–90. PMID 12694191.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki NN, Koizumi K, Fukushima M; et al. (2004). "Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2". Acta Crystallogr. D Biol. Crystallogr. 59 (Pt 8): 1477–8. PMID 12876357.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki NN, Koizumi K, Fukushima M; et al. (2005). "Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase". Structure. 12 (5): 751–64. doi:10.1016/j.str.2004.02.038. PMID 15130468.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murata D, Endo Y, Obata T; et al. (2005). "A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides". Drug Metab. Dispos. 32 (10): 1178–82. doi:10.1124/dmd.104.000737. PMID 15280220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aldenhoven J, Chen Y, Moran C (2006). "Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels". Cytogenet. Genome Res. 112 (3–4): 341F. doi:10.1159/000089896. PMID 16484797.CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)