AMY2B

Amylase, alpha 2B (pancreatic)
File:PBB Protein AMY2B image.jpg PDB rendering based on 1b2y.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1b2y​, 1bsi​, 1c8q​, 1cpu​, 1hny​, 1jxj​, 1jxk​, 1kb3​, 1kbb​, 1kbk​, 1kgu​, 1kgw​, 1kgx​, 1mfu​, 1mfv​, 1nm9​, 1q4n​, 1smd​, 1u2y​, 1u30​, 1u33​, 1xcw​, 1xcx​, 1xd0​, 1xd1​, 1xgz​, 1xh0​, 1xh1​, 1xh2​, 1xv8​, 1z32​, 2cpu​, 3cpu​
Identifiers
Symbols	AMY2B ; AMY2
External IDs	Template:OMIM5 HomoloGene: 88874
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Amylase, alpha 2B (pancreatic), also known as AMY2B, is a human gene.

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.

Further reading

• Kaczmarek MJ, Rosenmund H (1977). "The action of human pancreatic and salivary isoamylases on starch and glycogen". Clin. Chim. Acta. 79 (1): 69–73. PMID 890964.
• Groot PC, Mager WH, Henriquez NV; et al. (1991). "Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers". Genomics. 8 (1): 97–105. PMID 2081604.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yokouchi H, Horii A, Emi M; et al. (1990). "Cloning and characterization of a third type of human alpha-amylase gene, AMY2B". Gene. 90 (2): 281–6. PMID 2401405.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gumucio DL, Wiebauer K, Caldwell RM; et al. (1988). "Concerted evolution of human amylase genes". Mol. Cell. Biol. 8 (3): 1197–205. PMID 2452973.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH (1988). "Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene". Nucleic Acids Res. 16 (17): 8261–76. PMID 2458567.CS1 maint: Multiple names: authors list (link)
• Tomita N, Horii A, Doi S; et al. (1989). "A novel type of human alpha-amylase produced in lung carcinoid tumor". Gene. 76 (1): 11–8. PMID 2701942.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Groot PC, Bleeker MJ, Pronk JC; et al. (1989). "The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes". Genomics. 5 (1): 29–42. PMID 2788608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Groot PC, Bleeker MJ, Pronk JC; et al. (1988). "Human pancreatic amylase is encoded by two different genes". Nucleic Acids Res. 16 (10): 4724. PMID 3260028.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tricoli JV, Shows TB (1984). "Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1". Somat. Cell Mol. Genet. 10 (2): 205–10. PMID 6608795.
• Omichi K, Hase S (1994). "Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene". Biochim. Biophys. Acta. 1203 (2): 224–9. PMID 8268204.
• Nagase T, Nakayama M, Nakajima D; et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. PMID 11347906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aughsteen AA (2001). "A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas". Saudi medical journal. 22 (5): 410–5. PMID 11376382.
• Koyama I, Komine S, Iino N; et al. (2001). "alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues". Clin. Chim. Acta. 309 (1): 73–83. PMID 11408008.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iafrate AJ, Feuk L, Rivera MN; et al. (2004). "Detection of large-scale variation in the human genome". Nat. Genet. 36 (9): 949–51. doi:10.1038/ng1416. PMID 15286789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)