VTCN1

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V-set domain containing T cell activation inhibitor 1
Identifiers
Symbols VTCN1 ; B7-H4; B7H4; B7S1; B7X; B7h.5; FLJ22418; PRO1291; RP11-229A19.4; VCTN1
External IDs Template:OMIM5 Template:MGI HomoloGene: 11627
RNA expression pattern
File:PBB GE VTCN1 219768 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

V-set domain containing T cell activation inhibitor 1, also known as VTCN1, is a human gene.[1]

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM][1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Watanabe N, Gavrieli M, Sedy JR; et al. (2003). "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1". Nat. Immunol. 4 (7): 670–9. doi:10.1038/ni944. PMID 12796776.
  • Sica GL, Choi IH, Zhu G; et al. (2003). "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity". Immunity. 18 (6): 849–61. PMID 12818165.
  • Prasad DV, Richards S, Mai XM, Dong C (2003). "B7S1, a novel B7 family member that negatively regulates T cell activation". Immunity. 18 (6): 863–73. PMID 12818166.
  • Zang X, Loke P, Kim J; et al. (2003). "B7x: a widely expressed B7 family member that inhibits T cell activation". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10388–92. doi:10.1073/pnas.1434299100. PMID 12920180.
  • Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
  • Choi IH, Zhu G, Sica GL; et al. (2004). "Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family". J. Immunol. 171 (9): 4650–4. PMID 14568939.
  • Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
  • Salceda S, Tang T, Kmet M; et al. (2005). "The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation". Exp. Cell Res. 306 (1): 128–41. doi:10.1016/j.yexcr.2005.01.018. PMID 15878339.
  • Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
  • Kryczek I, Zou L, Rodriguez P; et al. (2006). "B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma". J. Exp. Med. 203 (4): 871–81. doi:10.1084/jem.20050930. PMID 16606666.
  • Kryczek I, Wei S, Zou L; et al. (2006). "Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells". J. Immunol. 177 (1): 40–4. PMID 16785496.
  • Krambeck AE, Thompson RH, Dong H; et al. (2006). "B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival". Proc. Natl. Acad. Sci. U.S.A. 103 (27): 10391–6. doi:10.1073/pnas.0600937103. PMID 16798883.
  • Chen Y, Yang C, Xie Z; et al. (2007). "Expression of the novel co-stimulatory molecule B7-H4 by renal tubular epithelial cells". Kidney Int. 70 (12): 2092–9. doi:10.1038/sj.ki.5001867. PMID 17051145.
  • Simon I, Katsaros D, Rigault de la Longrais I; et al. (2007). "B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression". Gynecol. Oncol. 106 (2): 334–41. doi:10.1016/j.ygyno.2007.03.035. PMID 17498784.
  • Miyatake T, Tringler B, Liu W; et al. (2007). "B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration". Gynecol. Oncol. 106 (1): 119–27. doi:10.1016/j.ygyno.2007.03.039. PMID 17509674.

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