FCN3

Ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
PDB rendering based on 2j5z.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2j5z​, 2j60​, 2j64​
Identifiers
Symbols	FCN3 ; FCNH; HAKA1; MGC22543
External IDs	Template:OMIM5 HomoloGene: 80190
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen), also known as FCN3, is a human gene.

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.

Further reading

• Yae Y, Inaba S, Sato H; et al. (1991). "Isolation and characterization of a thermolabile beta-2 macroglycoprotein ('thermolabile substance' or 'Hakata antigen') detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus". Biochim. Biophys. Acta. 1078 (3): 369–76. PMID 1859827.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inaba S, Okochi K, Yae Y; et al. (1991). "Serological studies of an SLE-associated antigen-antibody system discovered as a precipitation reaction in agarose gel: the HAKATA antigen-antibody system". Fukuoka Igaku Zasshi. 81 (9): 284–91. PMID 2276712.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sugimoto R, Yae Y, Akaiwa M; et al. (1998). "Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family". J. Biol. Chem. 273 (33): 20721–7. PMID 9694814.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akaiwa M, Yae Y, Sugimoto R; et al. (1999). "Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile". J. Histochem. Cytochem. 47 (6): 777–86. PMID 10330454.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsushita M, Kuraya M, Hamasaki N; et al. (2002). "Activation of the lectin complement pathway by H-ficolin (Hakata antigen)". J. Immunol. 168 (7): 3502–6. PMID 11907111.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsujimura M, Miyazaki T, Kojima E; et al. (2003). "Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth". Clin. Chim. Acta. 325 (1–2): 139–46. PMID 12367778.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zeng L, Dai J, Ying K; et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anderson NL, Polanski M, Pieper R; et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Muzny DM, Scherer SE, Kaul R; et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Garlatti V, Belloy N, Martin L; et al. (2007). "Structural insights into the innate immune recognition specificities of L- and H-ficolins". EMBO J. 26 (2): 623–33. doi:10.1038/sj.emboj.7601500. PMID 17215869.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Honoré C, Hummelshoj T, Hansen BE; et al. (2007). "The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells". Arthritis Rheum. 56 (5): 1598–607. doi:10.1002/art.22564. PMID 17469142.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)