INPP5B

Inositol polyphosphate-5-phosphatase, 75kDa
Identifiers
Symbols	INPP5B ; 5PTase; MGC65156; MGC71303
External IDs	Template:OMIM5 Template:MGI HomoloGene: 69021
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Inositol polyphosphate-5-phosphatase, 75kDa, also known as INPP5B, is a human gene.

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Further reading

• Ross TS, Jefferson AB, Mitchell CA, Majerus PW (1991). "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase". J. Biol. Chem. 266 (30): 20283–9. PMID 1718960.CS1 maint: Multiple names: authors list (link)
• Mitchell CA, Connolly TM, Majerus PW (1989). "Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets". J. Biol. Chem. 264 (15): 8873–7. PMID 2542294.CS1 maint: Multiple names: authors list (link)
• Jefferson AB, Majerus PW (1995). "Properties of type II inositol polyphosphate 5-phosphatase". J. Biol. Chem. 270 (16): 9370–7. PMID 7721860.
• Jänne PA, Dutra AS, Dracopoli NC; et al. (1994). "Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34". Cytogenet. Cell Genet. 66 (3): 164–6. PMID 8125013.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Speed CJ, Matzaris M, Bird PI, Mitchell CA (1996). "Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase". Eur. J. Biochem. 234 (1): 216–24. PMID 8529643.CS1 maint: Multiple names: authors list (link)
• Jänne PA, Rochelle JM, Martin-DeLeon PA; et al. (1996). "Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens". Genomics. 28 (2): 280–5. doi:10.1006/geno.1995.1142. PMID 8530037.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barrios-Rodiles M, Brown KR, Ozdamar B; et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)