SMCP

Sperm mitochondria-associated cysteine-rich protein
Identifiers
Symbols	SMCP ; MCSP; MCS; HSMCSGEN1; MGC26305; MGC26519
External IDs	Template:OMIM5
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SMCP 206406 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sperm mitochondria-associated cysteine-rich protein, also known as SMCP, is a human gene.

Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath.

Further reading

• Behne D, Kyriakopoulos A (2001). "Mammalian selenium-containing proteins". Annu. Rev. Nutr. 21: 453–73. doi:10.1146/annurev.nutr.21.1.453. PMID 11375445.
• Karimpour I, Cutler M, Shih D; et al. (1992). "Sequence of the gene encoding the mitochondrial capsule selenoprotein of mouse sperm: identification of three in-phase TGA selenocysteine codons". DNA Cell Biol. 11 (9): 693–9. PMID 1418626.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saaranen M, Suistomaa U, Vanha-Perttula T (1989). "Semen selenium content and sperm mitochondrial volume in human and some animal species". Hum. Reprod. 4 (3): 304–8. PMID 2715306.CS1 maint: Multiple names: authors list (link)
• Aho H, Schwemmer M, Tessman D; et al. (1997). "Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP)". Genomics. 32 (2): 184–90. PMID 8833144.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cataldo L, Baig K, Oko R; et al. (1997). "Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm". Mol. Reprod. Dev. 45 (3): 320–31. doi:10.1002/(SICI)1098-2795(199611)45:3<320::AID-MRD9>3.0.CO;2-U. PMID 8916043.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Herr JC, Thomas D, Bush LA; et al. (1999). "Sperm mitochondria-associated cysteine-rich protein (SMCP) is an autoantigen in Lewis rats". Biol. Reprod. 61 (2): 428–35. PMID 10411523.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nayernia K, Adham IM, Burkhardt-Göttges E; et al. (2002). "Asthenozoospermia in mice with targeted deletion of the sperm mitochondrion-associated cysteine-rich protein (Smcp) gene". Mol. Cell. Biol. 22 (9): 3046–52. PMID 11940662.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hawthorne SK, Goodarzi G, Bagarova J; et al. (2006). "Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene". Genomics. 87 (3): 382–91. doi:10.1016/j.ygeno.2005.09.010. PMID 16325371.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yatsenko AN, Roy A, Chen R; et al. (2007). "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization". Hum. Mol. Genet. 15 (23): 3411–9. doi:10.1093/hmg/ddl417. PMID 17047026.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)