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Ubiquitination factor E4B (UFD2 homolog, yeast), also known as UBE4B, is a human gene.[1]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes.[1]
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Koegl M, Hoppe T, Schlenker S; et al. (1999). "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly". Cell. 96 (5): 635–44. PMID10089879.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Ohira M, Kageyama H, Mihara M; et al. (2000). "Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line". Oncogene. 19 (37): 4302–7. doi:10.1038/sj.onc.1203786. PMID10980605.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Mahoney JA, Odin JA, White SM; et al. (2002). "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis". Biochem. J. 361 (Pt 3): 587–95. PMID11802788.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Kaneko C, Hatakeyama S, Matsumoto M; et al. (2003). "Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a". Biochem. Biophys. Res. Commun. 300 (2): 297–304. PMID12504083.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Krona C, Ejeskär K, Abel F; et al. (2003). "Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2". Oncogene. 22 (15): 2343–51. doi:10.1038/sj.onc.1206324. PMID12700669.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Okumura F, Hatakeyama S, Matsumoto M; et al. (2005). "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis". J. Biol. Chem. 279 (51): 53533–43. doi:10.1074/jbc.M402916200. PMID15466860.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Spinette S, Mahoney JA, Rosen A (2006). "The MPAC domain is a novel mitotically regulated domain, removed by apoptotic protease cleavage during cell death". Biochem. Biophys. Res. Commun. 347 (4): 1103–12. doi:10.1016/j.bbrc.2006.06.194. PMID16870146.CS1 maint: Multiple names: authors list (link)
Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
