ERRFI1
| ERBB receptor feedback inhibitor 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | ERRFI1 ; MIG6; GENE-33; MIG-6; RALT | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 10344 | ||||||||||
| |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
ERBB receptor feedback inhibitor 1, also known as ERRFI1, is a human gene.[1]
MIG6 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).[supplied by OMIM][1]
References
Further reading
- Zhang YW, Vande Woude GF (2007). "Mig-6, signal transduction, stress response and cancer". Cell Cycle. 6 (5): 507–13. PMID 17351343.
- Chrapkiewicz NB, Davis CM, Chu DT; et al. (1989). "Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity". Nucleic Acids Res. 17 (16): 6651–67. PMID 2780291.
- Wick M, Bürger C, Funk M, Müller R (1995). "Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation". Exp. Cell Res. 219 (2): 527–35. doi:10.1006/excr.1995.1261. PMID 7641805.
- Makkinje A, Quinn DA, Chen A; et al. (2000). "Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress". J. Biol. Chem. 275 (23): 17838–47. doi:10.1074/jbc.M909735199. PMID 10749885.
- Fiorentino L, Pertica C, Fiorini M; et al. (2000). "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain". Mol. Cell. Biol. 20 (20): 7735–50. PMID 11003669.
- Hackel PO, Gishizky M, Ullrich A (2002). "Mig-6 is a negative regulator of the epidermal growth factor receptor signal". Biol. Chem. 382 (12): 1649–62. PMID 11843178.
- Fiorini M, Ballarò C, Sala G; et al. (2002). "Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene. 21 (42): 6530–9. doi:10.1038/sj.onc.1205823. PMID 12226756.
- Tsunoda T, Inokuchi J, Baba I; et al. (2002). "A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6". Cancer Res. 62 (20): 5668–71. PMID 12384522.
- Saarikoski ST, Rivera SP, Hankinson O (2002). "Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia". FEBS Lett. 530 (1–3): 186–90. PMID 12387890.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Anastasi S, Fiorentino L, Fiorini M; et al. (2003). "Feedback inhibition by RALT controls signal output by the ErbB network". Oncogene. 22 (27): 4221–34. doi:10.1038/sj.onc.1206516. PMID 12833145.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Xu D, Makkinje A, Kyriakis JM (2005). "Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function". J. Biol. Chem. 280 (4): 2924–33. doi:10.1074/jbc.M408907200. PMID 15556944.
- Keeton AB, Messina JL (2005). "Modulation of Elk-dependent-transcription by Gene33". J. Cell. Biochem. 94 (6): 1190–8. doi:10.1002/jcb.20370. PMID 15696545.
- Benzinger A, Muster N, Koch HB; et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Anastasi S, Sala G, Huiping C; et al. (2005). "Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin". Oncogene. 24 (28): 4540–8. doi:10.1038/sj.onc.1208658. PMID 15856022.
- Ballarò C, Ceccarelli S, Tiveron C; et al. (2006). "Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype". EMBO Rep. 6 (8): 755–61. doi:10.1038/sj.embor.7400458. PMID 16007071.
- Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Zhang YW, Staal B, Su Y; et al. (2007). "Evidence that MIG-6 is a tumor-suppressor gene". Oncogene. 26 (2): 269–76. doi:10.1038/sj.onc.1209790. PMID 16819504.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |