S100A3
| S100 calcium binding protein A3 | |||||||||||||
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File:PBB Protein S100A3 image.jpg PDB rendering based on 1kso. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | S100A3 ; S100E | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2223 | ||||||||||||
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| RNA expression pattern | |||||||||||||
| File:PBB GE S100A3 206027 at tn.png | |||||||||||||
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| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||||
| RefSeq (protein) | n/a | n/a | |||||||||||
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S100 calcium binding protein A3, also known as S100A3, is a human gene.[1]
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown.[1]
References
Further reading
- Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends Biochem. Sci. 21 (4): 134–40. PMID 8701470.
- Föhr UG, Heizmann CW, Engelkamp D; et al. (1995). "Purification and cation binding properties of the recombinant human S100 calcium-binding protein A3, an EF-hand motif protein with high affinity for zinc". J. Biol. Chem. 270 (36): 21056–61. PMID 7673133.
- Schäfer BW, Wicki R, Engelkamp D; et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. PMID 7759097.
- Engelkamp D, Schäfer BW, Mattei MG; et al. (1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6547–51. PMID 8341667.
- Kizawa K, Uchiwa H, Murakami U (1996). "Highly-expressed S100A3, a calcium-binding protein, in human hair cuticle". Biochim. Biophys. Acta. 1312 (2): 94–8. PMID 8672544.
- Böni R, Burg G, Doguoglu A; et al. (1997). "Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions". Br. J. Dermatol. 137 (1): 39–43. PMID 9274623.
- Groves P, Finn BE, Kuźnicki J, Forsén S (1998). "A model for target protein binding to calcium-activated S100 dimers". FEBS Lett. 421 (3): 175–9. PMID 9468301.
- Ridinger K, Ilg EC, Niggli FK; et al. (1999). "Clustered organization of S100 genes in human and mouse". Biochim. Biophys. Acta. 1448 (2): 254–63. PMID 9920416.
- Fritz G, Heizmann CW, Kroneck PM (1999). "Probing the structure of the human Ca2+- and Zn2+-binding protein S100A3: spectroscopic investigations of its transition metal ion complexes, and three-dimensional structural model". Biochim. Biophys. Acta. 1448 (2): 264–76. PMID 9920417.
- Hoyaux D, Decaestecker C, Heizmann CW; et al. (2000). "S100 proteins in Corpora amylacea from normal human brain". Brain Res. 867 (1–2): 280–8. PMID 10837826.
- Fritz G, Mittl PR, Vasak M; et al. (2002). "The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution". J. Biol. Chem. 277 (36): 33092–8. doi:10.1074/jbc.M200574200. PMID 12045193.
- Mittl PR, Fritz G, Sargent DF; et al. (2003). "Metal-free MIRAS phasing: structure of apo-S100A3". Acta Crystallogr. D Biol. Crystallogr. 58 (Pt 8): 1255–61. PMID 12136135.
- Kizawa K, Troxler H, Kleinert P; et al. (2003). "Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles". Biochem. Biophys. Res. Commun. 299 (5): 857–62. PMID 12470658.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
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