LRP2

Low density lipoprotein-related protein 2
Identifiers
Symbols	LRP2 ; gp330
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20952
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LRP2 205710 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Low density lipoprotein-related protein 2, also known as LRP2, is a protein forming a receptor found in the plasma membrane of human cells involved in receptor-mediated endocytosis.

Lipoprotein receptor-related protein-2 (LRP2), also called glycoprotein 330 or megalin (Farquhar, 1995), is part of the Heymann nephritis antigenic complex with RAP (LRPAP1; MIM 104225) (Farquhar et al., 1995) and is a member of a family of receptors with structural similarities to the low density lipoprotein receptor (LDLR; MIM 606945).[supplied by OMIM]

Further reading

• Farquhar MG, Saito A, Kerjaschki D, Orlando RA (1995). "The Heymann nephritis antigenic complex: megalin (gp330) and RAP". J. Am. Soc. Nephrol. 6 (1): 35–47. PMID 7579068.CS1 maint: Multiple names: authors list (link)
• Farquhar MG (1995). "The unfolding story of megalin (gp330): now recognized as a drug receptor". J. Clin. Invest. 96 (3): 1184. PMID 7657789.
• Christensen EI, Birn H (2002). "Megalin and cubilin: multifunctional endocytic receptors". Nat. Rev. Mol. Cell Biol. 3 (4): 256–66. doi:10.1038/nrm778. PMID 11994745.
• Saito A, Takeda T, Hama H; et al. (2006). "Role of megalin, a proximal tubular endocytic receptor, in the pathogenesis of diabetic and metabolic syndrome-related nephropathies: protein metabolic overload hypothesis". Nephrology (Carlton, Vic.). 10 Suppl: S26–31. doi:10.1111/j.1440-1797.2005.00453.x. PMID 16174284.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fisher CE, Howie SE (2006). "The role of megalin (LRP-2/Gp330) during development". Dev. Biol. 296 (2): 279–97. doi:10.1016/j.ydbio.2006.06.007. PMID 16828734.
• Christensen EI, Gliemann J, Moestrup SK (1992). "Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein". J. Histochem. Cytochem. 40 (10): 1481–90. PMID 1382088.CS1 maint: Multiple names: authors list (link)
• Raychowdhury R, Niles JL, McCluskey RT, Smith JA (1989). "Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor". Science. 244 (4909): 1163–5. PMID 2786251.CS1 maint: Multiple names: authors list (link)
• Orlando RA, Farquhar MG (1994). "Functional domains of the receptor-associated protein (RAP)". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3161–5. PMID 7512726.
• Kounnas MZ, Chappell DA, Strickland DK, Argraves WS (1993). "Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro". J. Biol. Chem. 268 (19): 14176–81. PMID 7686151.CS1 maint: Multiple names: authors list (link)
• Kounnas MZ, Loukinova EB, Stefansson S; et al. (1995). "Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin". J. Biol. Chem. 270 (22): 13070–5. PMID 7768901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Korenberg JR, Argraves KM, Chen XN; et al. (1994). "Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1)". Genomics. 22 (1): 88–93. doi:10.1006/geno.1994.1348. PMID 7959795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lundgren S, Hjälm G, Hellman P; et al. (1994). "A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily". Exp. Cell Res. 212 (2): 344–50. PMID 8187828.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moestrup SK, Nielsen S, Andreasen P; et al. (1993). "Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes". J. Biol. Chem. 268 (22): 16564–70. PMID 8344937.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hjälm G, Murray E, Crumley G; et al. (1996). "Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties". Eur. J. Biochem. 239 (1): 132–7. PMID 8706697.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Willnow TE, Hilpert J, Armstrong SA; et al. (1996). "Defective forebrain development in mice lacking gp330/megalin". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8460–4. PMID 8710893.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cui S, Verroust PJ, Moestrup SK, Christensen EI (1996). "Megalin/gp330 mediates uptake of albumin in renal proximal tubule". Am. J. Physiol. 271 (4 Pt 2): F900–7. PMID 8898021.CS1 maint: Multiple names: authors list (link)
• Lundgren S, Carling T, Hjälm G; et al. (1997). "Tissue distribution of human gp330/megalin, a putative Ca(2+)-sensing protein". J. Histochem. Cytochem. 45 (3): 383–92. PMID 9071320.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Birn H, Verroust PJ, Nexo E; et al. (1997). "Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein". J. Biol. Chem. 272 (42): 26497–504. PMID 9334227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)