Natriuretic peptide precursor C

Natriuretic peptide precursor C
Identifiers
Symbols	NPPC ; CNP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7867
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NPPC 221348 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Natriuretic peptide precursor C, also known as NPPC, is a human gene.

Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP; MIM 108780), brain natriuretic peptide (BNP; MIM 600295), and C-type natriuretic peptide, CNP, encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.[supplied by OMIM]

Further reading

• Schulz S (2005). "C-type natriuretic peptide and guanylyl cyclase B receptor". Peptides. 26 (6): 1024–34. doi:10.1016/j.peptides.2004.08.027. PMID 15911070.
• Suga S, Nakao K, Hosoda K; et al. (1992). "Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide". Endocrinology. 130 (1): 229–39. PMID 1309330.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogawa Y, Nakao K, Nakagawa O; et al. (1992). "Human C-type natriuretic peptide. Characterization of the gene and peptide". Hypertension. 19 (6 Pt 2): 809–13. PMID 1339402.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishizaka Y, Kangawa K, Minamino N; et al. (1993). "Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1". Biochem. Biophys. Res. Commun. 189 (2): 697–704. PMID 1472040.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Komatsu Y, Nakao K, Suga S; et al. (1991). "C-type natriuretic peptide (CNP) in rats and humans". Endocrinology. 129 (2): 1104–6. PMID 1855454.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tawaragi Y, Fuchimura K, Tanaka S; et al. (1991). "Gene and precursor structures of human C-type natriuretic peptide". Biochem. Biophys. Res. Commun. 175 (2): 645–51. PMID 2018508.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogawa Y, Itoh H, Yoshitake Y; et al. (1995). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaneko T, Shirakami G, Nakao K; et al. (1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Res. 612 (1–2): 104–9. PMID 8330189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wei CM, Heublein DM, Perrella MA; et al. (1993). "Natriuretic peptide system in human heart failure". Circulation. 88 (3): 1004–9. PMID 8353861.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Igaki T, Itoh H, Suga S; et al. (1996). "Insulin suppresses endothelial secretion of C-type natriuretic peptide, a novel endothelium-derived relaxing peptide". Diabetes. 45 Suppl 3: S62–4. PMID 8674895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Igaki T, Itoh H, Suga S; et al. (1996). "C-type natriuretic peptide in chronic renal failure and its action in humans". Kidney Int. Suppl. 55: S144–7. PMID 8743538.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vollmar AM, Paumgartner G, Gerbes AL (1997). "Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver". Gut. 40 (1): 145–50. PMID 9155593.CS1 maint: Multiple names: authors list (link)
• Watanabe Y, Nakajima K, Shimamori Y, Fujimoto Y (1997). "Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11". Biochem. Mol. Med. 61 (1): 47–51. PMID 9232196.CS1 maint: Multiple names: authors list (link)
• He Xl , Chow Dc , Martick MM, Garcia KC (2001). "Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone". Science. 293 (5535): 1657–62. doi:10.1126/science.1062246. PMID 11533490.CS1 maint: Multiple names: authors list (link)
• Cataliotti A, Giordano M, De Pascale E; et al. (2002). "CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome". Am. J. Physiol. Renal Physiol. 283 (3): F464–72. doi:10.1152/ajprenal.00372.2001. PMID 12167597.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Evans JJ, Youssef AH, Yandle TG; et al. (2002). "Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells". J. Endocrinol. 175 (1): 225–32. PMID 12379507.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ono K, Mannami T, Baba S; et al. (2003). "A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension". Hypertens. Res. 25 (5): 727–30. PMID 12452325.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirsch JR, Skutta N, Schlatter E (2003). "Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B.". Am. J. Physiol. Renal Physiol. 285 (2): F370–4. doi:10.1152/ajprenal.00049.2003. PMID 12709393.CS1 maint: Multiple names: authors list (link)
• Wu C, Wu F, Pan J; et al. (2003). "Furin-mediated processing of Pro-C-type natriuretic peptide". J. Biol. Chem. 278 (28): 25847–52. doi:10.1074/jbc.M301223200. PMID 12736257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)