BIN1

Bridging integrator 1
PDB rendering based on 1bb9.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1bb9​, 1muz​, 1mv0​, 1mv3​, 2fic​
Identifiers
Symbols	BIN1 ; AMPH2; AMPHL; DKFZp547F068; MGC10367; SH3P9
External IDs	Template:OMIM5 Template:MGI HomoloGene: 62497
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Bridging integrator 1, also known as BIN1, is a human gene.

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Further reading

• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Negorev D, Riethman H, Wechsler-Reya R; et al. (1997). "The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization". Genomics. 33 (2): 329–31. doi:10.1006/geno.1996.0205. PMID 8725406.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC (1996). "BIN1 is a novel MYC-interacting protein with features of a tumour suppressor". Nat. Genet. 14 (1): 69–77. doi:10.1038/ng0996-69. PMID 8782822.CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leprince C, Romero F, Cussac D; et al. (1997). "A new member of the amphiphysin family connecting endocytosis and signal transduction pathways". J. Biol. Chem. 272 (24): 15101–5. PMID 9182529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Butler MH, David C, Ochoa GC; et al. (1997). "Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle". J. Cell Biol. 137 (6): 1355–67. PMID 9182667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS (1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform". J. Biol. Chem. 272 (26): 16700–6. PMID 9195986.CS1 maint: Multiple names: authors list (link)
• Tsutsui K, Maeda Y, Tsutsui K; et al. (1997). "cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants". Biochem. Biophys. Res. Commun. 236 (1): 178–83. doi:10.1006/bbrc.1997.6927. PMID 9223448.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McMahon HT, Wigge P, Smith C (1997). "Clathrin interacts specifically with amphiphysin and is displaced by dynamin". FEBS Lett. 413 (2): 319–22. PMID 9280305.CS1 maint: Multiple names: authors list (link)
• Micheva KD, Ramjaun AR, Kay BK, McPherson PS (1997). "SH3 domain-dependent interactions of endophilin with amphiphysin". FEBS Lett. 414 (2): 308–12. PMID 9315708.CS1 maint: Multiple names: authors list (link)
• Micheva KD, Kay BK, McPherson PS (1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. 272 (43): 27239–45. PMID 9341169.CS1 maint: Multiple names: authors list (link)
• Wigge P, Köhler K, Vallis Y; et al. (1997). "Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis". Mol. Biol. Cell. 8 (10): 2003–15. PMID 9348539.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kadlec L, Pendergast AM (1997). "The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12390–5. PMID 9356459.
• Wechsler-Reya R, Sakamuro D, Zhang J; et al. (1998). "Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing". J. Biol. Chem. 272 (50): 31453–8. PMID 9395479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wechsler-Reya RJ, Elliott KJ, Prendergast GC (1998). "A role for the putative tumor suppressor Bin1 in muscle cell differentiation". Mol. Cell. Biol. 18 (1): 566–75. PMID 9418903.CS1 maint: Multiple names: authors list (link)
• Ramjaun AR, McPherson PS (1998). "Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites". J. Neurochem. 70 (6): 2369–76. PMID 9603201.
• Mao NC, Steingrimsson E, DuHadaway J; et al. (1999). "The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2". Genomics. 56 (1): 51–8. doi:10.1006/geno.1998.5709. PMID 10036185.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wixler V, Laplantine E, Geerts D; et al. (1999). "Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains". FEBS Lett. 445 (2–3): 351–5. PMID 10094488.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ramjaun AR, Philie J, de Heuvel E, McPherson PS (1999). "The N terminus of amphiphysin II mediates dimerization and plasma membrane targeting". J. Biol. Chem. 274 (28): 19785–91. PMID 10391921.CS1 maint: Multiple names: authors list (link)
• Traub LM, Downs MA, Westrich JL, Fremont DH (1999). "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 8907–12. PMID 10430869.CS1 maint: Multiple names: authors list (link)