EIF2AK3

Eukaryotic translation initiation factor 2-alpha kinase 3
Identifiers
Symbols	EIF2AK3 ; WRS; DKFZp781H1925; PEK; PERK
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3557
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Eukaryotic translation initiation factor 2-alpha kinase 3, also known as EIF2AK3, is a human gene.

Further reading

• Mellor H, Proud CG (1991). "A synthetic peptide substrate for initiation factor-2 kinases". Biochem. Biophys. Res. Commun. 178 (2): 430–7. PMID 1677563.
• Dever TE, Chen JJ, Barber GN; et al. (1993). "Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4616–20. PMID 8099443.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shi Y, Vattem KM, Sood R; et al. (1998). "Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control". Mol. Cell. Biol. 18 (12): 7499–509. PMID 9819435.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shi Y, An J, Liang J; et al. (1999). "Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells". J. Biol. Chem. 274 (9): 5723–30. PMID 10026192.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hayes SE, Conner LJ, Stramm LE, Shi Y (2000). "Assignment of pancreatic eIF-2alpha kinase (EIF2AK3) to human chromosome band 2p12 by radiation hybrid mapping and in situ hybridization". Cytogenet. Cell Genet. 86 (3–4): 327–8. PMID 10575235.CS1 maint: Multiple names: authors list (link)
• Sood R, Porter AC, Ma K; et al. (2000). "Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress". Biochem. J. 346 Pt 2: 281–93. PMID 10677345.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Delépine M, Nicolino M, Barrett T; et al. (2000). "EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome". Nat. Genet. 25 (4): 406–9. doi:10.1038/78085. PMID 10932183.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saelens X, Kalai M, Vandenabeele P (2001). "Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation". J. Biol. Chem. 276 (45): 41620–8. doi:10.1074/jbc.M103674200. PMID 11555640.CS1 maint: Multiple names: authors list (link)
• Ma K, Vattem KM, Wek RC (2002). "Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress". J. Biol. Chem. 277 (21): 18728–35. doi:10.1074/jbc.M200903200. PMID 11907036.CS1 maint: Multiple names: authors list (link)
• Okada T, Yoshida H, Akazawa R; et al. (2002). "Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response". Biochem. J. 366 (Pt 2): 585–94. doi:10.1042/BJ20020391. PMID 12014989.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Biason-Lauber A, Lang-Muritano M, Vaccaro T, Schoenle EJ (2002). "Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene". Diabetes. 51 (7): 2301–5. PMID 12086964.CS1 maint: Multiple names: authors list (link)
• Koumenis C, Naczki C, Koritzinsky M; et al. (2002). "Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha". Mol. Cell. Biol. 22 (21): 7405–16. PMID 12370288.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marcu MG, Doyle M, Bertolotti A; et al. (2003). "Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha". Mol. Cell. Biol. 22 (24): 8506–13. PMID 12446770.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan W, Frank CL, Korth MJ; et al. (2003). "Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 15920–5. doi:10.1073/pnas.252341799. PMID 12446838.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pavio N, Romano PR, Graczyk TM; et al. (2003). "Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK". J. Virol. 77 (6): 3578–85. PMID 12610133.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cullinan SB, Zhang D, Hannink M; et al. (2003). "Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival". Mol. Cell. Biol. 23 (20): 7198–209. PMID 14517290.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Senée V, Vattem KM, Delépine M; et al. (2004). "Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity". Diabetes. 53 (7): 1876–83. PMID 15220213.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Allotey RA, Mohan V, McDermott MF; et al. (2005). "The EIF2AK3 gene region and type I diabetes in subjects from South India". Genes Immun. 5 (8): 648–52. doi:10.1038/sj.gene.6364139. PMID 15483661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)