WIPF1

WAS/WASL interacting protein family, member 1
File:PBB Protein WIPF1 image.jpg PDB rendering based on 2a41.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2a41​
Identifiers
Symbols	WIPF1 ; MGC111041; PRPL-2; WASPIP; WIP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 86891
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE WIPF1 202664 at tn.png
File:PBB GE WIPF1 202663 at tn.png
File:PBB GE WIPF1 202665 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WAS/WASL interacting protein family, member 1, also known as WIPF1, is a human gene.

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene.

Further reading

• Ramesh N, Antón IM, Martínez-Quiles N, Geha RS (1999). "Waltzing with WASP". Trends Cell Biol. 9 (1): 15–9. PMID 10087612.CS1 maint: Multiple names: authors list (link)
• Ramesh N, Antón IM, Hartwig JH, Geha RS (1998). "WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14671–6. PMID 9405671.CS1 maint: Multiple names: authors list (link)
• Antón IM, Lu W, Mayer BJ; et al. (1998). "The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck". J. Biol. Chem. 273 (33): 20992–5. PMID 9694849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stewart DM, Tian L, Nelson DL (1999). "Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein". J. Immunol. 162 (8): 5019–24. PMID 10202051.CS1 maint: Multiple names: authors list (link)
• Vaduva G, Martinez-Quiles N, Anton IM; et al. (1999). "The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast". J. Biol. Chem. 274 (24): 17103–8. PMID 10358064.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moreau V, Frischknecht F, Reckmann I; et al. (2000). "A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization". Nat. Cell Biol. 2 (7): 441–8. doi:10.1038/35017080. PMID 10878810.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vetterkind S, Miki H, Takenawa T; et al. (2002). "The rat homologue of Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation". J. Biol. Chem. 277 (1): 87–95. doi:10.1074/jbc.M104555200. PMID 11687573.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Antón IM, de la Fuente MA, Sims TN; et al. (2002). "WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation". Immunity. 16 (2): 193–204. PMID 11869681.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scott MP, Zappacosta F, Kim EY; et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Benesch S, Lommel S, Steffen A; et al. (2002). "Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2". J. Biol. Chem. 277 (40): 37771–6. doi:10.1074/jbc.M204145200. PMID 12147689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zettl M, Way M (2003). "The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs". Curr. Biol. 12 (18): 1617–22. PMID 12372256.
• Volkman BF, Prehoda KE, Scott JA; et al. (2002). "Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome". Cell. 111 (4): 565–76. PMID 12437929.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sasahara Y, Rachid R, Byrne MJ; et al. (2003). "Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation". Mol. Cell. 10 (6): 1269–81. PMID 12504004.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luthi JN, Gandhi MJ, Drachman JG (2003). "X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP)". Exp. Hematol. 31 (2): 150–8. PMID 12591280.CS1 maint: Multiple names: authors list (link)
• Kinley AW, Weed SA, Weaver AM; et al. (2003). "Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion". Curr. Biol. 13 (5): 384–93. PMID 12620186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim MK, Kim ES, Kim DS; et al. (2004). "Two novel mutations of Wiskott-Aldrich syndrome: the molecular prediction of interaction between the mutated WASP L101P with WASP-interacting protein by molecular modeling". Biochim. Biophys. Acta. 1690 (2): 134–40. doi:10.1016/j.bbadis.2004.06.007. PMID 15469902.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)