CRYGB
| Crystallin, gamma B | |||||||||||
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| Symbols | CRYGB ; CRYG2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3816 | ||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Crystallin, gamma B, also known as CRYGB, is a human gene.[1]
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.[1]
References
Further reading
- Graw J (1998). "The crystallins: genes, proteins and diseases". Biol. Chem. 378 (11): 1331–48. PMID 9426193.
- Slingsby C, Clout NJ (2000). "Structure of the crystallins". Eye (London, England). 13 ( Pt 3b): 395–402. PMID 10627816.
- Hearne CM, Todd JA (1991). "Trinucleotide repeat polymorphism at the CRYG1 locus". Nucleic Acids Res. 19 (19): 5450. PMID 1923840.
- Brakenhoff RH, Aarts HJ, Reek FH; et al. (1991). "Human gamma-crystallin genes. A gene family on its way to extinction". J. Mol. Biol. 216 (3): 519–32. PMID 2258929.
- den Dunnen JT, van Neck JW, Cremers FP; et al. (1989). "Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region". Gene. 78 (2): 201–13. PMID 2777080.
- Shiloh Y, Donlon T, Bruns G; et al. (1986). "Assignment of the human gamma-crystallin gene cluster (CRYG) to the long arm of chromosome 2, region q33-36". Hum. Genet. 73 (1): 17–9. PMID 3011643.
- Meakin SO, Du RP, Tsui LC, Breitman ML (1987). "Gamma-crystallins of the human eye lens: expression analysis of five members of the gene family". Mol. Cell. Biol. 7 (8): 2671–9. PMID 3670288.
- den Dunnen JT, Moormann RJ, Cremers FP, Schoenmakers JG (1986). "Two human gamma-crystallin genes are linked and riddled with Alu-repeats". Gene. 38 (1–3): 197–204. PMID 4065573.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
- Héon E, Priston M, Schorderet DF; et al. (1999). "The gamma-crystallins and human cataracts: a puzzle made clearer". Am. J. Hum. Genet. 65 (5): 1261–7. PMID 10521291.
- Santhiya ST, Shyam Manohar M, Rawlley D; et al. (2002). "Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts". J. Med. Genet. 39 (5): 352–8. PMID 12011157.
- MacCoss MJ, McDonald WH, Saraf A; et al. (2002). "Shotgun identification of protein modifications from protein complexes and lens tissue". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7900–5. doi:10.1073/pnas.122231399. PMID 12060738.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Salim A, Zaidi ZH (2003). "Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins". Biochem. Biophys. Res. Commun. 300 (3): 624–30. PMID 12507494.
- Nandrot E, Slingsby C, Basak A; et al. (2003). "Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts". J. Med. Genet. 40 (4): 262–7. PMID 12676897.
- Lapko VN, Smith DL, Smith JB (2004). "Methylation and carbamylation of human gamma-crystallins". Protein Sci. 12 (8): 1762–74. PMID 12876325.
- Salim A, Bano A, Zaidi ZH (2004). "Prediction of possible sites for posttranslational modifications in human gamma crystallins: effect of glycation on the structure of human gamma-B-crystallin as analyzed by molecular modeling". Proteins. 53 (2): 162–73. doi:10.1002/prot.10493. PMID 14517968.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
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