GAL3ST2

Galactose-3-O-sulfotransferase 2
Identifiers
Symbols	GAL3ST2 ; GAL3ST-2; GP3ST
External IDs	Template:OMIM5 Template:MGI HomoloGene: 41471
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Galactose-3-O-sulfotransferase 2, also known as GAL3ST2, is a human gene.

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2.

Further reading

• Honke K, Tsuda M, Koyota S; et al. (2001). "Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides". J. Biol. Chem. 276 (1): 267–74. doi:10.1074/jbc.M005666200. PMID 11029462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Venter JC, Adams MD, Myers EW; et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki A, Hiraoka N, Suzuki M; et al. (2001). "Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans". J. Biol. Chem. 276 (26): 24388–95. doi:10.1074/jbc.M103135200. PMID 11323440.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seko A, Hara-Kuge S, Yamashita K (2001). "Molecular cloning and characterization of a novel human galactose 3-O-sulfotransferase that transfers sulfate to gal beta 1-->3galNAc residue in O-glycans". J. Biol. Chem. 276 (28): 25697–704. doi:10.1074/jbc.M101558200. PMID 11333265.CS1 maint: Multiple names: authors list (link)
• Ikeda N, Eguchi H, Nishihara S; et al. (2001). "A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x epitopes". J. Biol. Chem. 276 (42): 38588–94. doi:10.1074/jbc.M107390200. PMID 11504739.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koma M, Miyagawa S, Honke K; et al. (2002). "The possibility of reducing xenoantigen levels with a novel gal 3'-sulfotransferase (GP3ST)". J. Biochem. 131 (4): 517–22. PMID 11926988.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seko A, Nagata K, Yonezawa S, Yamashita K (2003). "Down-regulation of Gal 3-O-sulfotransferase-2 (Gal3ST-2) expression in human colonic non-mucinous adenocarcinoma". Jpn. J. Cancer Res. 93 (5): 507–15. PMID 12036446.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chandrasekaran EV, Lakhaman SS, Chawda R; et al. (2004). "Identification of physiologically relevant substrates for cloned Gal: 3-O-sulfotransferases (Gal3STs): distinct high affinity of Gal3ST-2 and LS180 sulfotransferase for the globo H backbone, Gal3ST-3 for N-glycan multiterminal Galbeta1, 4GlcNAcbeta units and 6-sulfoGalbeta1, 4GlcNAcbeta, and Gal3ST-4 for the mucin core-2 trisaccharide". J. Biol. Chem. 279 (11): 10032–41. doi:10.1074/jbc.M311989200. PMID 14701868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shi BZ, Hu P, Geng F; et al. (2005). "Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins". Biochem. Biophys. Res. Commun. 332 (4): 934–40. doi:10.1016/j.bbrc.2005.05.040. PMID 15921657.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seko A, Sumiya J, Yamashita K (2006). "Porcine, mouse and human galactose 3-O-sulphotransferase-2 enzymes have different substrate specificities; the porcine enzyme requires basic compounds for its catalytic activity". Biochem. J. 391 (Pt 1): 77–85. doi:10.1042/BJ20050362. PMID 15926885.CS1 maint: Multiple names: authors list (link)