BOK (gene)
| BCL2-related ovarian killer | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | BOK ; BCL2L9; BOKL; MGC4631 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 9632 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
 | |||||||||||
 | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
BCL2-related ovarian killer, also known as BOK, is a human gene.[1]
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains all four BCL-2 like domains (BH1, 2, 3 and 4) and is a pro-apoptotic BCL-2 protein identified in the ovary.[1]
References
Further reading
- Hsu SY, Kaipia A, McGee E; et al. (1997). "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12401–6. PMID 9356461.
- Inohara N, Ekhterae D, Garcia I; et al. (1998). "Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL". J. Biol. Chem. 273 (15): 8705–10. PMID 9535847.
- Leo CP, Hsu SY, Chun SY; et al. (1999). "Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary". Endocrinology. 140 (12): 5469–77. PMID 10579309.
- Zhang H, Huang Q, Ke N; et al. (2000). "Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms". J. Biol. Chem. 275 (35): 27303–6. doi:10.1074/jbc.M002846200. PMID 10811653.
- Zhang H, Holzgreve W, De Geyter C (2000). "Evolutionarily conserved Bok proteins in the Bcl-2 family". FEBS Lett. 480 (2–3): 311–3. PMID 11034351.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Yakovlev AG, Di Giovanni S, Wang G; et al. (2004). "BOK and NOXA are essential mediators of p53-dependent apoptosis". J. Biol. Chem. 279 (27): 28367–74. doi:10.1074/jbc.M313526200. PMID 15102863.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Soleymanlou N, Wu Y, Wang JX; et al. (2005). "A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia". Cell Death Differ. 12 (5): 441–52. doi:10.1038/sj.cdd.4401593. PMID 15775999.
- Gao S, Fu W, Dürrenberger M; et al. (2005). "Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3". Cell. Mol. Life Sci. 62 (9): 1015–24. doi:10.1007/s00018-005-4543-3. PMID 15868100.
- Bartholomeusz G, Wu Y, Ali Seyed M; et al. (2006). "Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis". Mol. Carcinog. 45 (2): 73–83. doi:10.1002/mc.20156. PMID 16302269.
- Rodriguez JM, Glozak MA, Ma Y, Cress WD (2006). "Bok, Bcl-2-related Ovarian Killer, Is Cell Cycle-regulated and Sensitizes to Stress-induced Apoptosis". J. Biol. Chem. 281 (32): 22729–35. doi:10.1074/jbc.M604705200. PMID 16772296.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |