C1D
| Nuclear DNA-binding protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | C1D ; MGC12261; MGC14659; SUNCOR | ||||||||
| External IDs | Template:OMIM5 HomoloGene: 89227 | ||||||||
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| Orthologs | |||||||||
| Template:GNF Ortholog box | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | n/a | n/a | |||||||
| Ensembl | n/a | n/a | |||||||
| UniProt | n/a | n/a | |||||||
| RefSeq (mRNA) | n/a | n/a | |||||||
| RefSeq (protein) | n/a | n/a | |||||||
| Location (UCSC) | n/a | n/a | |||||||
| PubMed search | n/a | n/a | |||||||
Nuclear DNA-binding protein, also known as C1D, is a human gene.[1]
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined.[1]
References
Further reading
- Schilders G, Egberts WV, Raijmakers R, Pruijn GJ (2007). "C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome". Arthritis Rheum. 56 (7): 2449–54. doi:10.1002/art.22710. PMID 17599775.
- Schilders G, van Dijk E, Pruijn GJ (2007). "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing". Nucleic Acids Res. 35 (8): 2564–72. doi:10.1093/nar/gkm082. PMID 17412707.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Rothbarth K, Stammer H, Werner D. "Proteasome-mediated degradation antagonizes critical levels of the apoptosis-inducing C1D protein". 2 (1): 12. PMID 12379155.
- Erdemir T, Bilican B, Oncel D; et al. (2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". J. Cell. Sci. 115 (Pt 1): 207–16. PMID 11801738.
- Rothbarth K, Hunziker A, Stammer H, Werner D (2001). "Promoter of the gene encoding the 16 kDa DNA-binding and apoptosis-inducing C1D protein". Biochim. Biophys. Acta. 1518 (3): 271–5. PMID 11311939.
- Rothbarth K, Spiess E, Juodka B; et al. (1999). "Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D". J. Cell. Sci. 112 ( Pt 13): 2223–32. PMID 10362552.
- Haataja L, Groffen J, Heisterkamp N (1999). "Identification of a novel Rac3-interacting protein C1D". Int. J. Mol. Med. 1 (4): 665–70. PMID 9852280.
- Yavuzer U, Smith GC, Bliss T; et al. (1998). "DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D". Genes Dev. 12 (14): 2188–99. PMID 9679063.
- Nehls P, Keck T, Greferath R; et al. (1998). "cDNA cloning, recombinant expression and characterization of polypetides with exceptional DNA affinity". Nucleic Acids Res. 26 (5): 1160–6. PMID 9469821.
- Zamir I, Dawson J, Lavinsky RM; et al. (1998). "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14400–5. PMID 9405624.
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