MGAT5

Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
Identifiers
Symbols	MGAT5 ; GNT-V
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1808
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE MGAT5 206720 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, also known as MGAT5, is a human gene.

This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies.

Further reading

• Dennis JW, Granovsky M, Warren CE (2000). "Glycoprotein glycosylation and cancer progression". Biochim. Biophys. Acta. 1473 (1): 21–34. PMID 10580127.CS1 maint: Multiple names: authors list (link)
• Saito H, Nishikawa A, Gu J; et al. (1994). "cDNA cloning and chromosomal mapping of human N-acetylglucosaminyltransferase V+". Biochem. Biophys. Res. Commun. 198 (1): 318–27. PMID 8292036.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Buckhaults P, Chen L, Fregien N, Pierce M (1997). "Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene". J. Biol. Chem. 272 (31): 19575–81. PMID 9235963.CS1 maint: Multiple names: authors list (link)
• Park C, Jin UH, Lee YC; et al. (1999). "Characterization of UDP-N-acetylglucosamine:alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B". Arch. Biochem. Biophys. 367 (2): 281–8. doi:10.1006/abbi.1999.1252. PMID 10395745.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Granovsky M, Fata J, Pawling J; et al. (2000). "Suppression of tumor growth and metastasis in Mgat5-deficient mice". Nat. Med. 6 (3): 306–12. doi:10.1038/73163. PMID 10700233.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ihara S, Miyoshi E, Ko JH; et al. (2002). "Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching". J. Biol. Chem. 277 (19): 16960–7. doi:10.1074/jbc.M200673200. PMID 11864986.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saito T, Miyoshi E, Sasai K; et al. (2002). "A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity". J. Biol. Chem. 277 (19): 17002–8. doi:10.1074/jbc.M200521200. PMID 11872751.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dosaka-Akita H, Miyoshi E, Suzuki O; et al. (2004). "Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers". Clin. Cancer Res. 10 (5): 1773–9. PMID 15014031.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guo P, Zhang Y, Shen ZH; et al. (2004). "Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferases". FEBS Lett. 562 (1–3): 93–8. doi:10.1016/S0014-5793(04)00188-7. PMID 15044007.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim CH (2005). "Increased expression of N-acetylglucosaminyltransferase-V in human hepatoma cells by retinoic acid and 1alpha,25-dihydroxyvitamin D3". Int. J. Biochem. Cell Biol. 36 (11): 2307–19. doi:10.1016/j.biocel.2004.04.021. PMID 15313475.
• Tomiie M, Isaka S, Miyoshi E; et al. (2005). "Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta". Biochem. Biophys. Res. Commun. 330 (3): 999–1004. doi:10.1016/j.bbrc.2005.02.186. PMID 15809094.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fang H, Huang W, Xu YY; et al. (2006). "Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7,721 cells". Cell Res. 16 (1): 82–92. doi:10.1038/sj.cr.7310011. PMID 16467879.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishimura H, Takahashi T, Nakagawa H; et al. (2006). "N-acetylglucosaminyltransferase V and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancer". Clin. Cancer Res. 12 (8): 2506–11. doi:10.1158/1078-0432.CCR-05-1938. PMID 16638859.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang L, Liang Y, Li Z; et al. (2007). "Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721". J. Cell. Biochem. 100 (1): 230–41. doi:10.1002/jcb.21071. PMID 16924681.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li J, Wang XM, Wang Q; et al. (2007). "Down-regulation of N-acetylglucosaminyltransferase-V induces ER stress by changing glycosylation and function of GLUT1". Arch. Biochem. Biophys. 463 (1): 102–9. doi:10.1016/j.abb.2007.03.005. PMID 17451637.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kudo T, Nakagawa H, Takahashi M; et al. (2007). "N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma". Mol. Cancer. 6: 32. doi:10.1186/1476-4598-6-32. PMID 17488527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)