RAPGEF4

Rap guanine nucleotide exchange factor (GEF) 4
File:PBB Protein RAPGEF4 image.jpg PDB rendering based on 1o7f.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1o7f​, 2byv​
Identifiers
Symbols	RAPGEF4 ; CAMP-GEFII; CGEF2; EPAC2; Nbla00496
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4451
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RAPGEF4 205651 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Rap guanine nucleotide exchange factor (GEF) 4, also known as RAPGEF4, is a human gene.

Further reading

• Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW (2002). "Ras and relatives--job sharing and networking keep an old family together". Exp. Hematol. 30 (10): 1089–106. PMID 12384139.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Kawasaki H, Springett GM, Mochizuki N; et al. (1999). "A family of cAMP-binding proteins that directly activate Rap1". Science. 282 (5397): 2275–9. PMID 9856955.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Rooij J, Rehmann H, van Triest M; et al. (2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs". J. Biol. Chem. 275 (27): 20829–36. doi:10.1074/jbc.M001113200. PMID 10777494.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ozaki N, Shibasaki T, Kashima Y; et al. (2001). "cAMP-GEFII is a direct target of cAMP in regulated exocytosis". Nat. Cell Biol. 2 (11): 805–11. doi:10.1038/35041046. PMID 11056535.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coppola T, Magnin-Luthi S, Perret-Menoud V; et al. (2001). "Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin". J. Biol. Chem. 276 (35): 32756–62. doi:10.1074/jbc.M100929200. PMID 11438518.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kashima Y, Miki T, Shibasaki T; et al. (2002). "Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion". J. Biol. Chem. 276 (49): 46046–53. doi:10.1074/jbc.M108378200. PMID 11598134.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueno H, Shibasaki T, Iwanaga T; et al. (2002). "Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform". Genomics. 78 (1–2): 91–8. doi:10.1006/geno.2001.6641. PMID 11707077.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rehmann H, Prakash B, Wolf E; et al. (2007). "Structure and regulation of the cAMP-binding domains of Epac2". Nat. Struct. Biol. 10 (1): 26–32. doi:10.1038/nsb878. PMID 12469113.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bacchelli E, Blasi F, Biondolillo M; et al. (2004). "Screening of nine candidate genes for autism on chromosome 2q reveals rare nonsynonymous variants in the cAMP-GEFII gene". Mol. Psychiatry. 8 (11): 916–24. doi:10.1038/sj.mp.4001340. PMID 14593429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shibasaki T, Sunaga Y, Fujimoto K; et al. (2004). "Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis". J. Biol. Chem. 279 (9): 7956–61. doi:10.1074/jbc.M309068200. PMID 14660679.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Magiera MM, Gupta M, Rundell CJ; et al. (2005). "Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A". Biochem. J. 382 (Pt 3): 803–10. doi:10.1042/BJ20040122. PMID 15202935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dupuy AG, L'Hoste S, Cherfils J; et al. (2005). "Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac". Oncogene. 24 (28): 4509–20. doi:10.1038/sj.onc.1208647. PMID 15856025.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ster J, De Bock F, Guérineau NC; et al. (2007). "Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons". Proc. Natl. Acad. Sci. U.S.A. 104 (7): 2519–24. doi:10.1073/pnas.0611031104. PMID 17284589.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)