NLRC4

NLR family, CARD domain containing 4
Identifiers
Symbols	NLRC4 ; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; IPAF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10924
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

NLR family, CARD domain containing 4, also known as NLRC4, is a human gene.

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1 (CARD4; MIM 605980), and NOD2 (CARD15; MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM]

Further reading

• Geddes BJ, Wang L, Huang WJ; et al. (2001). "Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis". Biochem. Biophys. Res. Commun. 284 (1): 77–82. doi:10.1006/bbrc.2001.4928. PMID 11374873.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Poyet JL, Srinivasula SM, Tnani M; et al. (2001). "Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1". J. Biol. Chem. 276 (30): 28309–13. doi:10.1074/jbc.C100250200. PMID 11390368.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Damiano JS, Stehlik C, Pio F; et al. (2001). "CLAN, a novel human CED-4-like gene". Genomics. 75 (1–3): 77–83. doi:10.1006/geno.2001.6579. PMID 11472070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fu WN, Bertoni F, Kelsey SM; et al. (2003). "Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia". Oncogene. 22 (3): 451–5. doi:10.1038/sj.onc.1206147. PMID 12545166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Agostini L, Martinon F, Burns K; et al. (2004). "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder". Immunity. 20 (3): 319–25. PMID 15030775.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Damiano JS, Oliveira V, Welsh K, Reed JC (2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses". Biochem. J. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMID 15107016.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Damiano JS, Newman RM, Reed JC (2004). "Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune response". J. Immunol. 173 (10): 6338–45. PMID 15528373.CS1 maint: Multiple names: authors list (link)
• Sadasivam S, Gupta S, Radha V; et al. (2005). "Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis". Oncogene. 24 (4): 627–36. doi:10.1038/sj.onc.1208201. PMID 15580302.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu C, Wang A, Wang L; et al. (2005). "Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation". Biochem. Biophys. Res. Commun. 331 (4): 1114–9. doi:10.1016/j.bbrc.2005.04.027. PMID 15882992.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thalappilly S, Sadasivam S, Radha V, Swarup G (2006). "Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis". FEBS J. 273 (12): 2766–78. doi:10.1111/j.1742-4658.2006.05293.x. PMID 16817903.CS1 maint: Multiple names: authors list (link)