MARCO

Macrophage receptor with collagenous structure
Identifiers
Symbols	MARCO ; SCARA2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4928
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MARCO 205819 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Macrophage receptor with collagenous structure, also known as MARCO, is a human gene.

The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.

Further reading

• Elomaa O, Kangas M, Sahlberg C; et al. (1995). "Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages". Cell. 80 (4): 603–9. PMID 7867067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Elomaa O, Sankala M, Pikkarainen T; et al. (1998). "Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region". J. Biol. Chem. 273 (8): 4530–8. PMID 9468508.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kangas M, Brännström A, Elomaa O; et al. (1999). "Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor". Genomics. 58 (1): 82–9. doi:10.1006/geno.1999.5811. PMID 10331948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Elshourbagy NA, Li X, Terrett J; et al. (2000). "Molecular characterization of a human scavenger receptor, human MARCO". Eur. J. Biochem. 267 (3): 919–26. PMID 10651831.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seta N, Granfors K, Sahly H; et al. (2001). "Expression of host defense scavenger receptors in spondylarthropathy". Arthritis Rheum. 44 (4): 931–9. doi:10.1002/1529-0131(200104)44:4<931::AID-ANR150>3.0.CO;2-T. PMID 11315932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brännström A, Sankala M, Tryggvason K, Pikkarainen T (2002). "Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO". Biochem. Biophys. Res. Commun. 290 (5): 1462–9. doi:10.1006/bbrc.2002.6378. PMID 11820786.CS1 maint: Multiple names: authors list (link)
• Sankala M, Brännström A, Schulthess T; et al. (2002). "Characterization of recombinant soluble macrophage scavenger receptor MARCO". J. Biol. Chem. 277 (36): 33378–85. doi:10.1074/jbc.M204494200. PMID 12097327.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mirani M, Elenkov I, Volpi S; et al. (2002). "HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection". J. Immunol. 169 (11): 6361–8. PMID 12444143.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bin LH, Nielson LD, Liu X; et al. (2003). "Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair". J. Immunol. 171 (2): 924–30. PMID 12847263.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arredouani MS, Palecanda A, Koziel H; et al. (2005). "MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages". J. Immunol. 175 (9): 6058–64. PMID 16237101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)