TLK1

Tousled-like kinase 1
Identifiers
Symbols	TLK1 ; KIAA0137; PKU-BETA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8185
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TLK1 202606 s at tn.png
File:PBB GE TLK1 210379 s at tn.png
File:PBB GE TLK1 211077 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tousled-like kinase 1, also known as TLK1, is a human gene.

The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
• Nagase T, Seki N, Tanaka A; et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. PMID 8590280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamakawa A, Kameoka Y, Hashimoto K; et al. (1998). "cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal". Gene. 202 (1–2): 193–201. PMID 9427565.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Silljé HH, Takahashi K, Tanaka K; et al. (1999). "Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication". EMBO J. 18 (20): 5691–702. doi:10.1093/emboj/18.20.5691. PMID 10523312.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cabaniols JP, Ravichandran V, Roche PA (2000). "Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly". Mol. Biol. Cell. 10 (12): 4033–41. PMID 10588641.CS1 maint: Multiple names: authors list (link)
• Li Y, DeFatta R, Anthony C; et al. (2001). "A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed". Oncogene. 20 (6): 726–38. doi:10.1038/sj.onc.1204147. PMID 11314006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Silljé HH, Nigg EA (2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Curr. Biol. 11 (13): 1068–73. PMID 11470414.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Groth A, Lukas J, Nigg EA; et al. (2003). "Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint". EMBO J. 22 (7): 1676–87. doi:10.1093/emboj/cdg151. PMID 12660173.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krause DR, Jonnalagadda JC, Gatei MH; et al. (2003). "Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1". Oncogene. 22 (38): 5927–37. doi:10.1038/sj.onc.1206691. PMID 12955071.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Norton KS, McClusky D, Sen S; et al. (2004). "TLK1B is elevated with eIF4E overexpression in breast cancer". J. Surg. Res. 116 (1): 98–103. PMID 14732354.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kodym R, Henöckl C, Fürweger C (2005). "Identification of the human DEAD-box protein p68 as a substrate of Tlk1". Biochem. Biophys. Res. Commun. 333 (2): 411–7. doi:10.1016/j.bbrc.2005.05.136. PMID 15950181.CS1 maint: Multiple names: authors list (link)
• Sunavala-Dossabhoy G, Balakrishnan SK, Sen S; et al. (2006). "The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks". BMC Mol. Biol. 6: 19. doi:10.1186/1471-2199-6-19. PMID 16156902.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sen SP, De Benedetti A (2006). "TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1". BMC Mol. Biol. 7: 37. doi:10.1186/1471-2199-7-37. PMID 17054786.