IL12A
| Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | |||||||||||||
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 PDB rendering based on 1f45. | |||||||||||||
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| Symbols | IL12A ; CLMF; IL-12A; NFSK; NKSF1 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 681 | ||||||||||||
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| Species | Human | Mouse | |||||||||||
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Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), also known as IL12A, is a human gene.
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.[1]
References
Further reading
- Airoldi I, Guglielmino R, Carra G; et al. (2002). "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes". Haematologica. 87 (4): 434–42. PMID 11940489.
- Muthumani K, Desai BM, Hwang DS; et al. (2004). "HIV-1 Vpr and anti-inflammatory activity". DNA Cell Biol. 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381.
- Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
- Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
- Peluso I, Pallone F, Monteleone G (2006). "Interleukin-12 and Th1 immune response in Crohn's disease: pathogenetic relevance and therapeutic implication". World J. Gastroenterol. 12 (35): 5606–10. PMID 17007011.
- Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". FASEB J. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296.
- Small RD (1976). "Letter: Statistical analysis of respiratory sensitivity to CO2". N. Engl. J. Med. 295 (7): 397. PMID 934235.
- Schoenhaut DS, Chua AO, Wolitzky AG; et al. (1992). "Cloning and expression of murine IL-12". J. Immunol. 148 (11): 3433–40. PMID 1350290.
- Sieburth D, Jabs EW, Warrington JA; et al. (1992). "Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5". Genomics. 14 (1): 59–62. PMID 1358798.
- Wolf SF, Temple PA, Kobayashi M; et al. (1991). "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells". J. Immunol. 146 (9): 3074–81. PMID 1673147.
- Gubler U, Chua AO, Schoenhaut DS; et al. (1991). "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4143–7. PMID 1674604.
- Kubin M, Kamoun M, Trinchieri G (1994). "Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells". J. Exp. Med. 180 (1): 211–22. PMID 7516408.
- Ling P, Gately MK, Gubler U; et al. (1995). "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity". J. Immunol. 154 (1): 116–27. PMID 7527811.
- Sharma V, Knobloch TJ, Benjamin D (1995). "Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines". Biochem. Biophys. Res. Commun. 208 (2): 704–13. doi:10.1006/bbrc.1995.1395. PMID 7695626.
- Radrizzani M, Accornero P, Amidei A; et al. (1995). "IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation". Cell. Immunol. 161 (1): 14–21. doi:10.1006/cimm.1995.1003. PMID 7867080.
- Fantuzzi L, Gessani S, Borghi P; et al. (1996). "Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion". J. Virol. 70 (6): 4121–4. PMID 8648753.
- Thierfelder WE, van Deursen JM, Yamamoto K; et al. (1996). "Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells". Nature. 382 (6587): 171–4. doi:10.1038/382171a0. PMID 8700208.
- Cella M, Scheidegger D, Palmer-Lehmann K; et al. (1996). "Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation". J. Exp. Med. 184 (2): 747–52. PMID 8760829.
- Taoufik Y, Lantz O, Wallon C; et al. (1997). "Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect". Blood. 89 (8): 2842–8. PMID 9108403.
- Kim JH, Loveland JE, Sitz KV; et al. (1997). "Expansion of restricted cellular immune responses to HIV-1 envelope by vaccination: IL-7 and IL-12 differentially augment cellular proliferative responses to HIV-1". Clin. Exp. Immunol. 108 (2): 243–50. PMID 9158092.
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