RFC4

Replication factor C (activator 1) 4, 37kDa
Identifiers
Symbols	RFC4 ; A1; MGC27291; RFC37
External IDs	Template:OMIM5 Template:MGI HomoloGene: 6288
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RFC4 204023 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Replication factor C (activator 1) 4, 37kDa, also known as RFC4, is a human gene.

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.

Further reading

• Chen M, Pan ZQ, Hurwitz J (1992). "Studies of the cloned 37-kDa subunit of activator 1 (replication factor C) of HeLa cells". Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5211–5. PMID 1351677.CS1 maint: Multiple names: authors list (link)
• Okumura K, Nogami M, Taguchi H; et al. (1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics. 25 (1): 274–8. PMID 7774928.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uhlmann F, Cai J, Flores-Rozas H; et al. (1996). "In vitro reconstitution of human replication factor C from its five subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521–6. PMID 8692848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cujec TP, Cho H, Maldonado E; et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. PMID 9121429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cai J, Gibbs E, Uhlmann F; et al. (1997). "A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme". J. Biol. Chem. 272 (30): 18974–81. PMID 9228079.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Loor G, Zhang SJ, Zhang P; et al. (1998). "Identification of DNA replication and cell cycle proteins that interact with PCNA". Nucleic Acids Res. 25 (24): 5041–6. PMID 9396813.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ellison V, Stillman B (1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity". J. Biol. Chem. 273 (10): 5979–87. PMID 9488738.
• Zhang G, Gibbs E, Kelman Z; et al. (1999). "Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1869–74. PMID 10051561.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uchiumi F, Watanabe M, Tanuma S (1999). "Characterization of telomere-binding activity of replication factor C large subunit p140". Biochem. Biophys. Res. Commun. 258 (2): 482–9. PMID 10329413.CS1 maint: Multiple names: authors list (link)
• van der Kuip H, Carius B, Haque SJ; et al. (1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins". J. Mol. Med. 77 (4): 386–92. PMID 10353443.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chaib H, Cockrell EK, Rubin MA, Macoska JA (2001). "Profiling and verification of gene expression patterns in normal and malignant human prostate tissues by cDNA microarray analysis". Neoplasia. 3 (1): 43–52. doi:10.1038/sj/neo/7900126. PMID 11326315.CS1 maint: Multiple names: authors list (link)
• Naiki T, Kondo T, Nakada D; et al. (2001). "Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway". Mol. Cell. Biol. 21 (17): 5838–45. PMID 11486023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A (2001). "Purification and characterization of human DNA damage checkpoint Rad complexes". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11236–41. doi:10.1073/pnas.201373498. PMID 11572977.CS1 maint: Multiple names: authors list (link)
• Griffith JD, Lindsey-Boltz LA, Sancar A (2002). "Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy". J. Biol. Chem. 277 (18): 15233–6. doi:10.1074/jbc.C200129200. PMID 11907025.CS1 maint: Multiple names: authors list (link)
• Anderson LA, Perkins ND (2002). "The large subunit of replication factor C interacts with the histone deacetylase, HDAC1". J. Biol. Chem. 277 (33): 29550–4. doi:10.1074/jbc.M200513200. PMID 12045192.
• Ohta S, Shiomi Y, Sugimoto K; et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama T, Farina A, Dey A; et al. (2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase". Mol. Cell. Biol. 22 (18): 6509–20. PMID 12192049.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anderson LA, Perkins ND (2003). "Regulation of RelA (p65) function by the large subunit of replication factor C.". Mol. Cell. Biol. 23 (2): 721–32. PMID 12509469.
• Nagata T, Takahashi Y, Ishii Y; et al. (2004). "Profiling of genes differentially expressed between fetal liver and postnatal liver using high-density oligonucleotide DNA array". Int. J. Mol. Med. 11 (6): 713–21. PMID 12736711.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)