ROBO1

Roundabout, axon guidance receptor, homolog 1 (Drosophila)
Identifiers
Symbols	ROBO1 ; DUTT1; FLJ21882; MGC131599; MGC133277; SAX3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2206
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Roundabout, axon guidance receptor, homolog 1 (Drosophila), also known as ROBO1, is a human gene.

Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. In Drosophila, the roundabout gene, a member of the immunoglobulin gene superfamily, encodes an integral membrane protein that is both an axon guidance receptor and a cell adhesion receptor. This receptor is involved in the decision by axons to cross the central nervous system midline. The protein encoded by this gene is structurally similar to the Drosophila roundabout protein. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Kidd T, Brose K, Mitchell KJ; et al. (1998). "Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors". Cell. 92 (2): 205–15. PMID 9458045.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sundaresan V, Roberts I, Bateman A; et al. (1998). "The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression". Mol. Cell. Neurosci. 11 (1–2): 29–35. doi:10.1006/mcne.1998.0672. PMID 9608531.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sundaresan V, Chung G, Heppell-Parton A; et al. (1998). "Homozygous deletions at 3p12 in breast and lung cancer". Oncogene. 17 (13): 1723–9. doi:10.1038/sj.onc.1202103. PMID 9796701.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brose K, Bland KS, Wang KH; et al. (1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance". Cell. 96 (6): 795–806. PMID 10102268.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yuan W, Zhou L, Chen JH; et al. (1999). "The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance". Dev. Biol. 212 (2): 290–306. doi:10.1006/dbio.1999.9371. PMID 10433822.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bashaw GJ, Kidd T, Murray D; et al. (2000). "Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor". Cell. 101 (7): 703–15. PMID 10892742.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nguyen Ba-Charvet KT, Brose K, Ma L; et al. (2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance". J. Neurosci. 21 (12): 4281–9. PMID 11404413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wong K, Ren XR, Huang YZ; et al. (2001). "Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway". Cell. 107 (2): 209–21. PMID 11672528.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dallol A, Forgacs E, Martinez A; et al. (2002). "Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers". Oncogene. 21 (19): 3020–8. doi:10.1038/sj.onc.1205421. PMID 12082532.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Latil A, Chêne L, Cochant-Priollet B; et al. (2003). "Quantification of expression of netrins, slits and their receptors in human prostate tumors". Int. J. Cancer. 103 (3): 306–15. doi:10.1002/ijc.10821. PMID 12471613.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hivert B, Liu Z, Chuang CY; et al. (2003). "Robo1 and Robo2 are homophilic binding molecules that promote axonal growth". Mol. Cell. Neurosci. 21 (4): 534–45. PMID 12504588.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang B, Xiao Y, Ding BB; et al. (2004). "Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity". Cancer Cell. 4 (1): 19–29. PMID 12892710.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hannula-Jouppi K, Kaminen-Ahola N, Taipale M; et al. (2006). "The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia". PLoS Genet. 1 (4): e50. doi:10.1371/journal.pgen.0010050. PMID 16254601.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Werbowetski-Ogilvie TE, Seyed Sadr M, Jabado N; et al. (2006). "Inhibition of medulloblastoma cell invasion by Slit". Oncogene. 25 (37): 5103–12. doi:10.1038/sj.onc.1209524. PMID 16636676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Muzny DM, Scherer SE, Kaul R; et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gröne J, Doebler O, Loddenkemper C; et al. (2007). "Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer". Oncol. Rep. 15 (6): 1437–43. PMID 16685377.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito H, Funahashi S, Yamauchi N; et al. (2007). "Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target". Clin. Cancer Res. 12 (11 Pt 1): 3257–64. doi:10.1158/1078-0432.CCR-05-2787. PMID 16740745.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)