MYL3

Myosin, light chain 3, alkali; ventricular, skeletal, slow
Identifiers
Symbols	MYL3 ; CMH8; MLC1V; VLC1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20099
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE MYL3 205589 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Myosin, light chain 3, alkali; ventricular, skeletal, slow, also known as MYL3, is a human gene.

MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.

Further reading

• Schaub MC, Hefti MA, Zuellig RA, Morano I (1998). "Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms". Cardiovasc. Res. 37 (2): 381–404. PMID 9614495.CS1 maint: Multiple names: authors list (link)
• Shi Q, Li RK, Mickle DA, Jackowski G (1993). "Analysis of the upstream regulatory region of human ventricular myosin light chain 1 gene". J. Mol. Cell. Cardiol. 24 (11): 1221–9. PMID 1479618.CS1 maint: Multiple names: authors list (link)
• Stragier P, Kunkel B, Kroos L, Losick R (1989). "Chromosomal rearrangement generating a composite gene for a developmental transcription factor". Science. 243 (4890): 507–12. PMID 2536191.CS1 maint: Multiple names: authors list (link)
• Cohen-Haguenauer O, Barton PJ, Van Cong N; et al. (1989). "Chromosomal assignment of two myosin alkali light-chain genes encoding the ventricular/slow skeletal muscle isoform and the atrial/fetal muscle isoform (MYL3, MYL4)". Hum. Genet. 81 (3): 278–82. PMID 2784124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fodor WL, Darras B, Seharaseyon J; et al. (1989). "Human ventricular/slow twitch myosin alkali light chain gene characterization, sequence, and chromosomal location". J. Biol. Chem. 264 (4): 2143–9. PMID 2789520.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoffmann E, Shi QW, Floroff M; et al. (1988). "Molecular cloning and complete nucleotide sequence of a human ventricular myosin light chain 1". Nucleic Acids Res. 16 (5): 2353. PMID 3357795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kurabayashi M, Komuro I, Tsuchimochi H; et al. (1988). "Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones". J. Biol. Chem. 263 (27): 13930–6. PMID 3417683.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Henry GD, Trayer IP, Brewer S, Levine BA (1985). "The widespread distribution of alpha-N-trimethylalanine as the N-terminal amino acid of light chains from vertebrate striated muscle myosins". Eur. J. Biochem. 148 (1): 75–82. PMID 3979397.CS1 maint: Multiple names: authors list (link)
• Kovalyov LI, Shishkin SS, Efimochkin AS; et al. (1996). "The major protein expression profile and two-dimensional protein database of human heart". Electrophoresis. 16 (7): 1160–9. PMID 7498159.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Poetter K, Jiang H, Hassanzadeh S; et al. (1996). "Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle". Nat. Genet. 13 (1): 63–9. doi:10.1038/ng0596-63. PMID 8673105.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeuchi K, Senba S, Furukawa K; et al. (1999). "Localization of 17-kDa myosin light chain isoforms in cultured aortic smooth muscle cells". J. Biochem. 125 (2): 334–42. PMID 9990131.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen PS, Havndrup O, Bundgaard H; et al. (2002). "Myosin light chain mutations in familial hypertrophic cardiomyopathy: phenotypic presentation and frequency in Danish and South African populations". J. Med. Genet. 38 (12): E43. PMID 11748309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olson TM, Karst ML, Whitby FG, Driscoll DJ (2002). "Myosin light chain mutation causes autosomal recessive cardiomyopathy with mid-cavitary hypertrophy and restrictive physiology". Circulation. 105 (20): 2337–40. PMID 12021217.CS1 maint: Multiple names: authors list (link)
• Moretti A, Weig HJ, Ott T; et al. (2002). "Essential myosin light chain as a target for caspase-3 in failing myocardium". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11860–5. doi:10.1073/pnas.182373099. PMID 12186978.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Richard P, Charron P, Carrier L; et al. (2003). "Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy". Circulation. 107 (17): 2227–32. doi:10.1161/01.CIR.0000066323.15244.54. PMID 12707239.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xie B, Huang R, Huang L; et al. (2004). "The functional domains of human ventricular myosin light chain 1". Biophys. Chem. 106 (1): 57–66. PMID 14516912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)