RAP2B

RAP2B, member of RAS oncogene family
File:PBB Protein RAP2B image.jpg PDB rendering based on 1kao.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1kao​, 2rap​, 3rap​
Identifiers
Symbols	RAP2B ; MGC20484
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55701
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RAP2B 213923 at tn.png
File:PBB GE RAP2B 214487 s at tn.png
File:PBB GE RAP2B 214488 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

RAP2B, member of RAS oncogene family, also known as RAP2B, is a human gene.

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.

Further reading

• Farrell FX, Ohmstede CA, Reep BR, Lapetina EG (1990). "cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2". Nucleic Acids Res. 18 (14): 4281. PMID 2115998.CS1 maint: Multiple names: authors list (link)
• Ohmstede CA, Farrell FX, Reep BR; et al. (1990). "RAP2B: a RAS-related GTP-binding protein from platelets". Proc. Natl. Acad. Sci. U.S.A. 87 (17): 6527–31. PMID 2118648.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pizon V, Chardin P, Lerosey I; et al. (1988). "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Oncogene. 3 (2): 201–4. PMID 3045729.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Torti M, Ramaschi G, Sinigaglia F; et al. (1993). "Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7553–7. PMID 8356055.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mollinedo F, Perez-Sala D, Gajate C; et al. (1993). "Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils". FEBS Lett. 326 (1–3): 209–14. PMID 8391995.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Farrell FX, Yamamoto K, Lapetina EG (1993). "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated". Biochem. J. 289 ( Pt 2): 349–55. PMID 8424780.CS1 maint: Multiple names: authors list (link)
• Nancy V, Wolthuis RM, de Tand MF; et al. (1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. PMID 10085114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rebhun JF, Castro AF, Quilliam LA (2001). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". J. Biol. Chem. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.CS1 maint: Multiple names: authors list (link)
• Nancy V, Callebaut I, El Marjou A, de Gunzburg J (2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539.CS1 maint: Multiple names: authors list (link)
• Evellin S, Nolte J, Tysack K; et al. (2002). "Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B". J. Biol. Chem. 277 (19): 16805–13. doi:10.1074/jbc.M112024200. PMID 11877431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song C, Satoh T, Edamatsu H; et al. (2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene. 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Greco F, Sinigaglia F, Balduini C, Torti M (2005). "Activation of the small GTPase Rap2B in agonist-stimulated human platelets". J. Thromb. Haemost. 2 (12): 2223–30. doi:10.1111/j.1538-7836.2004.01018.x. PMID 15613030.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu Y, Sun W, Zhang K; et al. (2007). "Identification of genes differentially expressed in human primary lung squamous cell carcinoma". Lung Cancer. 56 (3): 307–17. doi:10.1016/j.lungcan.2007.01.016. PMID 17316888.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)