EIF2A

Eukaryotic translation initiation factor 2A, 65kDa
Identifiers
Symbols	EIF2A ; EIF-2A; CDA02; MST089; MSTP004; MSTP089
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5969
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Eukaryotic translation initiation factor 2A, 65kDa, also known as EIF2A, is a human gene.

EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]

Further reading

• Merrick WC (1992). "Mechanism and regulation of eukaryotic protein synthesis". Microbiol. Rev. 56 (2): 291–315. PMID 1620067.
• Zoll WL, Horton LE, Komar AA; et al. (2002). "Characterization of mammalian eIF2A and identification of the yeast homolog". J. Biol. Chem. 277 (40): 37079–87. doi:10.1074/jbc.M207109200. PMID 12133843.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koumenis C, Naczki C, Koritzinsky M; et al. (2002). "Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha". Mol. Cell. Biol. 22 (21): 7405–16. PMID 12370288.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Page AB, Owen CR, Kumar R; et al. (2003). "Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia". Acta Neuropathol. 106 (1): 8–16. doi:10.1007/s00401-003-0693-2. PMID 12687390.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito T, Marintchev A, Wagner G (2005). "Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B". Structure. 12 (9): 1693–704. doi:10.1016/j.str.2004.07.010. PMID 15341733.CS1 maint: Multiple names: authors list (link)
• Weiser DC, Sikes S, Li S, Shenolikar S (2005). "The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms". J. Biol. Chem. 279 (47): 48904–14. doi:10.1074/jbc.M404416200. PMID 15345721.CS1 maint: Multiple names: authors list (link)
• Komar AA, Gross SR, Barth-Baus D; et al. (2005). "Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A". J. Biol. Chem. 280 (16): 15601–11. doi:10.1074/jbc.M413728200. PMID 15718232.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang J, Laschinger C, Zhao XH; et al. (2005). "Mechanical force activates eIF-2alpha phospho-kinases in fibroblast". Biochem. Biophys. Res. Commun. 330 (1): 123–30. doi:10.1016/j.bbrc.2005.02.140. PMID 15781241.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gorrini C, Loreni F, Gandin V; et al. (2005). "Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways". Proc. Natl. Acad. Sci. U.S.A. 102 (26): 9200–5. doi:10.1073/pnas.0409513102. PMID 15961545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Su Q, Wang S, Baltzis D; et al. (2006). "Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 103 (1): 63–8. doi:10.1073/pnas.0508207103. PMID 16373505.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Squatrito M, Mancino M, Sala L, Draetta GF (2006). "Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation". Biochem. Biophys. Res. Commun. 344 (3): 859–68. doi:10.1016/j.bbrc.2006.03.205. PMID 16631606.CS1 maint: Multiple names: authors list (link)
• Scheuner D, Patel R, Wang F; et al. (2006). "Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis". J. Biol. Chem. 281 (30): 21458–68. doi:10.1074/jbc.M603784200. PMID 16717090.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mazroui R, Sukarieh R, Bordeleau ME; et al. (2007). "Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation". Mol. Biol. Cell. 17 (10): 4212–9. doi:10.1091/mbc.E06-04-0318. PMID 16870703.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fribley AM, Evenchik B, Zeng Q; et al. (2006). "Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa". J. Biol. Chem. 281 (42): 31440–7. doi:10.1074/jbc.M604356200. PMID 16928686.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fritsch RM, Schneider G, Saur D; et al. (2007). "Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation". J. Biol. Chem. 282 (31): 22551–62. doi:10.1074/jbc.M702673200. PMID 17553788.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nayak R, Pintel DJ (2007). "Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA". J. Virol. 81 (21): 11908–16. doi:10.1128/JVI.01132-07. PMID 17715234.