Oxoguanine glycosylase

8-oxoguanine DNA glycosylase
File:PBB Protein OGG1 image.jpg PDB rendering based on 1ebm.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ebm​, 1fn7​, 1hu0​, 1ko9​, 1lwv​, 1lww​, 1lwy​, 1m3h​, 1m3q​, 1n39​, 1n3a​, 1n3c​, 1yqk​, 1yql​, 1yqm​, 1yqr​, 2i5w​, 2nob​, 2noe​, 2nof​, 2noh​, 2noi​, 2nol​, 2noz​
Identifiers
Symbols	OGG1 ; HMMH; HOGG1; MUTM; OGH1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1909
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE OGG1 205301 s at tn.png
File:PBB GE OGG1 205760 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Oxoguanine glycosylase is a DNA glycosylase enzyme. It is involved in base excision repair.

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. The N-terminus of this gene contains a mitochondrial targetting signal, essential for mitochondrial localization.

Further reading

• Boiteux S, Radicella JP (2000). "The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis". Arch. Biochem. Biophys. 377 (1): 1–8. doi:10.1006/abbi.2000.1773. PMID 10775435.
• Park J, Chen L, Tockman MS; et al. (2004). "The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk". Pharmacogenetics. 14 (2): 103–9. PMID 15077011.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hung RJ, Hall J, Brennan P, Boffetta P (2006). "Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review". Am. J. Epidemiol. 162 (10): 925–42. doi:10.1093/aje/kwi318. PMID 16221808.CS1 maint: Multiple names: authors list (link)

External links

• oxoguanine+glycosylase+1,+human at the US National Library of Medicine Medical Subject Headings (MeSH)