SCYE1

Small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
File:PBB Protein SCYE1 image.jpg PDB rendering based on 1e7z.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1e7z​, 1euj​, 1fl0​
Identifiers
Symbols	SCYE1 ; AIMP1; EMAP II; EMAP-2; EMAP-II; EMAP2; EMAPII; p43
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31260
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SCYE1 202542 s at tn.png
File:PBB GE SCYE1 202541 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating), also known as SCYE1, is a human gene.

The protein encoded by this gene is a cytokine that is specifically induced by apoptosis. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor of SCYE1 (pro-SCYE1) is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex. Therefore, pro-SCYE1 may function in binding RNA as part of the tRNA synthetase complex in normal cells and in stimulating inflammatory responses after proteolytic cleavage in tumor cells.

Further reading

• Kao J, Ryan J, Brett G; et al. (1992). "Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms". J. Biol. Chem. 267 (28): 20239–47. PMID 1400342.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kao J, Fan YG, Haehnel I; et al. (1994). "A peptide derived from the amino terminus of endothelial-monocyte-activating polypeptide II modulates mononuclear and polymorphonuclear leukocyte functions, defines an apparently novel cellular interaction site, and induces an acute inflammatory response". J. Biol. Chem. 269 (13): 9774–82. PMID 7545917.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kao J, Houck K, Fan Y; et al. (1994). "Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II". J. Biol. Chem. 269 (40): 25106–19. PMID 7929199.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Quevillon S, Agou F, Robinson JC, Mirande M (1998). "The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine". J. Biol. Chem. 272 (51): 32573–9. PMID 9405472.CS1 maint: Multiple names: authors list (link)
• Quevillon S, Robinson JC, Berthonneau E; et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". J. Mol. Biol. 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. PMID 9878398.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park SG, Jung KH, Lee JS; et al. (1999). "Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase". J. Biol. Chem. 274 (24): 16673–6. PMID 10358004.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim Y, Shin J, Li R; et al. (2000). "A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases". J. Biol. Chem. 275 (35): 27062–8. doi:10.1074/jbc.C000216200. PMID 10852899.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Renault L, Kerjan P, Pasqualato S; et al. (2001). "Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry". EMBO J. 20 (3): 570–8. doi:10.1093/emboj/20.3.570. PMID 11157763.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shalak V, Kaminska M, Mitnacht-Kraus R; et al. (2001). "The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component". J. Biol. Chem. 276 (26): 23769–76. doi:10.1074/jbc.M100489200. PMID 11306575.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang SY, Park SG, Kim S, Kang CY (2002). "Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation". J. Biol. Chem. 277 (10): 8388–94. doi:10.1074/jbc.M108792200. PMID 11741979.CS1 maint: Multiple names: authors list (link)
• Battersby S, Boddy SC, Critchley HO, Jabbour HN (2002). "Expression and localization of endothelial monocyte-activating polypeptide II in the human endometrium across the menstrual cycle: regulation of expression by prostaglandin E(2)". J. Clin. Endocrinol. Metab. 87 (8): 3928–35. PMID 12161535.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park H, Park SG, Kim J; et al. (2003). "Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43". Cytokine. 20 (4): 148–53. PMID 12543078.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ahn HC, Kim S, Lee BJ (2003). "Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43". FEBS Lett. 542 (1–3): 119–24. PMID 12729910.CS1 maint: Multiple names: authors list (link)
• Kim MJ, Park BJ, Kang YS; et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3): 330–6. doi:10.1038/ng1182. PMID 12819782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wolfe CL, Warrington JA, Davis S; et al. (2004). "Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII". Protein Sci. 12 (10): 2282–90. PMID 14500886.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mueller CA, Schluesener HJ, Conrad S; et al. (2004). "Spinal cord injury induces lesional expression of the proinflammatory and antiangiogenic cytokine EMAP II". J. Neurotrauma. 20 (10): 1007–15. doi:10.1089/089771503770195858. PMID 14588117.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murray JC, Symonds P, Ward W; et al. (2004). "Colorectal cancer cells induce lymphocyte apoptosis by an endothelial monocyte-activating polypeptide-II-dependent mechanism". J. Immunol. 172 (1): 274–81. PMID 14688335.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murray JC, Heng YM, Symonds P; et al. (2004). "Endothelial monocyte-activating polypeptide-II (EMAP-II): a novel inducer of lymphocyte apoptosis". J. Leukoc. Biol. 75 (5): 772–6. doi:10.1189/jlb.1003487. PMID 14982944.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)