SCARB2
| Scavenger receptor class B, member 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SCARB2 ; CD36L2; HLGP85; LIMPII; SR-BII | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 48353 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SCARB2 201647 s at tn.png | |||||||||||
| File:PBB GE SCARB2 201646 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Scavenger receptor class B, member 2, also known as SCARB2, is a human gene.[1]
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Studies of the similar protein in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. Deficiency of the similar protein in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy.[1]
References
Further reading
- Eskelinen EL, Tanaka Y, Saftig P (2003). "At the acidic edge: emerging functions for lysosomal membrane proteins". Trends Cell Biol. 13 (3): 137–45. PMID 12628346.
- Fujita H, Takata Y, Kono A; et al. (1992). "Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells". Biochem. Biophys. Res. Commun. 184 (2): 604–11. PMID 1374238.
- Sandoval IV, Arredondo JJ, Alcalde J; et al. (1994). "The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes". J. Biol. Chem. 269 (9): 6622–31. PMID 7509809.
- Calvo D, Dopazo J, Vega MA (1995). "The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution". Genomics. 25 (1): 100–6. PMID 7539776.
- Crombie R, Silverstein R (1998). "Lysosomal integral membrane protein II binds thrombospondin-1. Structure-function homology with the cell adhesion molecule CD36 defines a conserved recognition motif". J. Biol. Chem. 273 (9): 4855–63. PMID 9478926.
- Harris RA, Yang A, Stein RC; et al. (2002). "Cluster analysis of an extensive human breast cancer cell line protein expression map database". Proteomics. 2 (2): 212–23. PMID 11840567.
- Wistow G, Bernstein SL, Wyatt MK; et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
- Kuronita T, Eskelinen EL, Fujita H; et al. (2003). "A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology". J. Cell. Sci. 115 (Pt 21): 4117–31. PMID 12356916.
- Rodionov DG, Höning S, Silye A; et al. (2003). "Structural requirements for interactions between leucine-sorting signals and clathrin-associated adaptor protein complex AP3". J. Biol. Chem. 277 (49): 47436–43. doi:10.1074/jbc.M207149200. PMID 12370188.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gamp AC, Tanaka Y, Lüllmann-Rauch R; et al. (2003). "LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice". Hum. Mol. Genet. 12 (6): 631–46. PMID 12620969.
- Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
- Mulcahy JV, Riddell DR, Owen JS (2004). "Human scavenger receptor class B type II (SR-BII) and cellular cholesterol efflux". Biochem. J. 377 (Pt 3): 741–7. doi:10.1042/BJ20030307. PMID 14570588.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Eckhardt ER, Cai L, Shetty S; et al. (2006). "High density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif". J. Biol. Chem. 281 (7): 4348–53. doi:10.1074/jbc.M513154200. PMID 16368683.
- Gupta SN, Kloster MM, Rodionov DG, Bakke O (2007). "Re-routing of the invariant chain to the direct sorting pathway by introduction of an AP3-binding motif from LIMP II". Eur. J. Cell Biol. 85 (6): 457–67. doi:10.1016/j.ejcb.2006.02.001. PMID 16542748.
- Tserentsoodol N, Gordiyenko NV, Pascual I; et al. (2006). "Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors". Mol. Vis. 12: 1319–33. PMID 17110915.
- Grove J, Huby T, Stamataki Z; et al. (2007). "Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity". J. Virol. 81 (7): 3162–9. doi:10.1128/JVI.02356-06. PMID 17215280.
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