HGFAC

HGF activator
PDB rendering based on 1ybw.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ybw​, 1yc0​
Identifiers
Symbols	HGFAC ; HGFA; MGC138395; MGC138397
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1170
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

HGF activator, also known as HGFAC, is a human gene.

The protein encoded by this gene belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.

Further reading

• Nakamura T (1992). "Structure and function of hepatocyte growth factor". Prog. Growth Factor Res. 3 (1): 67–85. PMID 1838014.
• Shimomura T, Ochiai M, Kondo J, Morimoto Y (1992). "A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture". Cytotechnology. 8 (3): 219–29. PMID 1368819.CS1 maint: Multiple names: authors list (link)
• Miyazawa K, Shimomura T, Kitamura A; et al. (1993). "Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII". J. Biol. Chem. 268 (14): 10024–8. PMID 7683665.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimomura T, Kondo J, Ochiai M; et al. (1993). "Activation of the zymogen of hepatocyte growth factor activator by thrombin". J. Biol. Chem. 268 (30): 22927–32. PMID 8226803.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyazawa K, Shimomura T, Kitamura N (1996). "Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator". J. Biol. Chem. 271 (7): 3615–8. PMID 8631970.CS1 maint: Multiple names: authors list (link)
• Shimomura T, Denda K, Kitamura A; et al. (1997). "Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor". J. Biol. Chem. 272 (10): 6370–6. PMID 9045658.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawaguchi T, Qin L, Shimomura T; et al. (1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor". J. Biol. Chem. 272 (44): 27558–64. PMID 9346890.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyazawa K, Wang Y, Minoshima S; et al. (1999). "Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator". Eur. J. Biochem. 258 (2): 355–61. PMID 9874200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kataoka H, Shimomura T, Kawaguchi T; et al. (2001). "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment". J. Biol. Chem. 275 (51): 40453–62. doi:10.1074/jbc.M006412200. PMID 11013244.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kataoka H, Meng JY, Itoh H; et al. (2001). "Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta". Histochem. Cell Biol. 114 (6): 469–75. PMID 11201608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anderson NL, Polanski M, Pieper R; et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tjin EP, Derksen PW, Kataoka H; et al. (2004). "Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator". Blood. 104 (7): 2172–5. doi:10.1182/blood-2003-12-4386. PMID 15172968.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
• Shia S, Stamos J, Kirchhofer D; et al. (2005). "Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B". J. Mol. Biol. 346 (5): 1335–49. doi:10.1016/j.jmb.2004.12.048. PMID 15713485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tjin EP, Groen RW, Vogelzang I; et al. (2006). "Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma". Blood. 107 (2): 760–8. doi:10.1182/blood-2005-05-1929. PMID 16189274.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)