PLK4

Polo-like kinase 4 (Drosophila)
File:PBB Protein PLK4 image.jpg PDB rendering based on 1mby.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1mby​
Identifiers
Symbols	PLK4 ; SAK; STK18
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7962
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PLK4 204887 s at tn.png
File:PBB GE PLK4 204886 at tn.png
File:PBB GE PLK4 211088 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Polo-like kinase 4 (Drosophila), also known as PLK4, is a human gene.

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle.

Further reading

• Kleylein-Sohn J, Westendorf J, Le Clech M; et al. (2007). "Plk4-induced centriole biogenesis in human cells". Dev. Cell. 13 (2): 190–202. doi:10.1016/j.devcel.2007.07.002. PMID 17681131.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bettencourt-Dias M, Rodrigues-Martins A, Carpenter L; et al. (2006). "SAK/PLK4 is required for centriole duplication and flagella development". Curr. Biol. 15 (24): 2199–207. doi:10.1016/j.cub.2005.11.042. PMID 16326102.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Habedanck R, Stierhof YD, Wilkinson CJ, Nigg EA (2006). "The Polo kinase Plk4 functions in centriole duplication". Nat. Cell Biol. 7 (11): 1140–6. doi:10.1038/ncb1320. PMID 16244668.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li J, Tan M, Li L; et al. (2005). "SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing". Neoplasia. 7 (4): 312–23. PMID 15967108.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barrios-Rodiles M, Brown KR, Ozdamar B; et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Macmillan JC, Hudson JW, Bull S; et al. (2002). "Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer". Ann. Surg. Oncol. 8 (9): 729–40. PMID 11597015.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamashita Y, Kajigaya S, Yoshida K; et al. (2001). "Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase". J. Biol. Chem. 276 (42): 39012–20. doi:10.1074/jbc.M106249200. PMID 11489907.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hudson JW, Chen L, Fode C; et al. (2000). "Sak kinase gene structure and transcriptional regulation". Gene. 241 (1): 65–73. PMID 10607900.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.