Microsomal triglyceride transfer protein

Microsomal triglyceride transfer protein
Identifiers
Symbols	MTTP ; ABL; MTP; MGC149819; MGC149820
External IDs	Template:OMIM5 Template:MGI HomoloGene: 212
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MTTP 205675 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Microsomal triglyceride transfer protein, also known as MTTP, is a human gene.

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.

Further reading

• Luz JM, Lennarz WJ (1996). "Protein disulfide isomerase: a multifunctional protein of the endoplasmic reticulum". EXS. 77: 97–117. PMID 8856971.
• Wetterau JR, Lin MC, Jamil H (1997). "Microsomal triglyceride transfer protein". Biochim. Biophys. Acta. 1345 (2): 136–50. PMID 9106493.CS1 maint: Multiple names: authors list (link)
• Gordon DA (1997). "Recent advances in elucidating the role of the microsomal triglyceride transfer protein in apolipoprotein B lipoprotein assembly". Curr. Opin. Lipidol. 8 (3): 131–7. PMID 9211060.
• Ye J (2007). "Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus". PLoS Pathog. 3 (8): e108. doi:10.1371/journal.ppat.0030108. PMID 17784784.
• Wetterau JR, Aggerbeck LP, Bouma ME; et al. (1992). "Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia". Science. 258 (5084): 999–1001. PMID 1439810.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sharp D, Ricci B, Kienzle B; et al. (1994). "Human microsomal triglyceride transfer protein large subunit gene structure". Biochemistry. 33 (31): 9057–61. PMID 7545943.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shoulders CC, Narcisi TM, Read J; et al. (1995). "The abetalipoproteinemia gene is a member of the vitellogenin family and encodes an alpha-helical domain". Nat. Struct. Biol. 1 (5): 285–6. PMID 7664034.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hagan DL, Kienzle B, Jamil H, Hariharan N (1994). "Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators". J. Biol. Chem. 269 (46): 28737–44. PMID 7961826.CS1 maint: Multiple names: authors list (link)
• Shoulders CC, Brett DJ, Bayliss JD; et al. (1994). "Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein". Hum. Mol. Genet. 2 (12): 2109–16. PMID 8111381.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Sharp D, Blinderman L, Combs KA; et al. (1993). "Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia". Nature. 365 (6441): 65–9. doi:10.1038/365065a0. PMID 8361539.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Narcisi TM, Shoulders CC, Chester SA; et al. (1996). "Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemia". Am. J. Hum. Genet. 57 (6): 1298–310. PMID 8533758.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rehberg EF, Samson-Bouma ME, Kienzle B; et al. (1997). "A novel abetalipoproteinemia genotype. Identification of a missense mutation in the 97-kDa subunit of the microsomal triglyceride transfer protein that prevents complex formation with protein disulfide isomerase". J. Biol. Chem. 271 (47): 29945–52. PMID 8939939.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Linnik KM, Herscovitz H (1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state". J. Biol. Chem. 273 (33): 21368–73. PMID 9694898.
• Bradbury P, Mann CJ, Köchl S; et al. (1999). "A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase". J. Biol. Chem. 274 (5): 3159–64. PMID 9915855.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang J, Hegele RA (2000). "Microsomal triglyceride transfer protein (MTP) gene mutations in Canadian subjects with abetalipoproteinemia". Hum. Mutat. 15 (3): 294–5. doi:10.1002/(SICI)1098-1004(200003)15:3<294::AID-HUMU14>3.0.CO;2-E. PMID 10679949.